Cytokine Profiles in Children With Obstructive Sleep Apnea
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any - 12 |
| Updated: | 4/2/2016 |
| Start Date: | April 2006 |
| End Date: | December 2008 |
| Contact: | Fuad M Baroody, MD |
| Email: | fbaroody@surgery.bsd.uchicago.edu |
| Phone: | 773-702-4790 |
Local and Systemic Cytokine Profiles in Children With Obstructive Sleep Apnea and Controls
The purpose of this study is to compare the cytokine profile of tonsillar and peripheral
blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the
blood mononuclear cell cytokine secretion profile between patients with obstructive sleep
apnea and controls without apnea.
blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the
blood mononuclear cell cytokine secretion profile between patients with obstructive sleep
apnea and controls without apnea.
We will recruit subjects with OSA about to undergo adenotonsillectomy and collect a blood
sample and portion of their tonsils after the induction of general anesthesia. The
mononuclear cells will be isolated from both these tissues and stimulated with different
markers and cytokines assayed and compared. We will also recruit patients with no symptoms
of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the
parents fill out a sleep questionnaire. We will then collect blood samples from these
patients after the induction of anesthesia and examine the cytokine secretion profile and
compare it to that of the children with OSA.
sample and portion of their tonsils after the induction of general anesthesia. The
mononuclear cells will be isolated from both these tissues and stimulated with different
markers and cytokines assayed and compared. We will also recruit patients with no symptoms
of OSA undergoing unrelated elective surgery and ascertain the absence of OSA by having the
parents fill out a sleep questionnaire. We will then collect blood samples from these
patients after the induction of anesthesia and examine the cytokine secretion profile and
compare it to that of the children with OSA.
Inclusion Criteria:
- OSA documented by polysomnography and clinical symptoms.
- Patients with no symptoms of OSA and negative sleep questionnaire.
Exclusion Criteria:
- Significant systemic disease except mild asthma
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