Stopping Cavities Study: Diammine Silver Fluoride
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 8/10/2016 |
| Start Date: | January 2016 |
| End Date: | July 2016 |
Pragmatic Trial of Topical Diammine Silver Fluoride for Dental Caries Arrest
This study is being conducted to test whether the use of diammine silver fluoride (also
called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
Phase III RCT with two arms: (1) 38% diammine silver fluoride; (2) distilled fluoride free
water. Subjects are 200 preschool children in good general health with untreated tooth
decay. Intervention is topical application of the study drug to the open cavity. Primary
outcome is caries activity at 14-21 days.
water. Subjects are 200 preschool children in good general health with untreated tooth
decay. Intervention is topical application of the study drug to the open cavity. Primary
outcome is caries activity at 14-21 days.
Inclusion Criteria:
- Nyvad criteria 3
- Active carious lesion
Exclusion Criteria:
- Allergy to silver
- Stomatitis or oral ulcerative condition
- Weight less than 15 kg
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