Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin

Inclusion Criteria:

- Must be willing and able to provide written informed consent.

- Healthy, non-smoking, male or female between the ages of 18 and 55 years (inclusive).

- Body weight > 50 kg and BMI between 18 and 32 kg/m2 (inclusive).

- If female, is of non-child bearing potential (i.e., surgically [bilateral
oophorectomy, hysterectomy, hysteroscopic sterilization, or tubal ligation]. Or, is
naturally sterile [>12 consecutive months without menses]) with verification by
follicle stimulating hormone (FSH) at screening.

- If male and non-vasectomized, must agree to use a condom with spermicide or abstain
from sexual intercourse during the study until 30 days beyond the last dose of study
drug. No restrictions are required for a vasectomized male provided his vasectomy has
been performed 4 months or more prior to first dose of study drug. A male who has
been vasectomized less than 4 months prior to study start must follow the same
procedure as a non-vasectomized male.

Exclusion Criteria:

- Any clinically significant abnormal findings during physical examination including
blood pressure, heart rate or rhythm, clinical laboratory tests or 12-lead ECG.

- Evidence or history of clinically significant hematological, endocrine, pulmonary,
gastrointestinal, cardiovascular, renal, hepatic, neurological or psychiatric
disease.

- Thyroid stimulating hormone test at screening outside the normal range. Repeat
testing is allowed once at the discretion of the Investigator.

- Current or recent (<6 months) hepatobiliary disease; or aspartate aminotransferase
(AST), alanine aminotransferase (ALT) or direct bilirubin greater than the upper
limit of reference range at screening. Repeat testing is allowed once at the
discretion of the Investigator.

- Elevated creatine kinase (CK) at screening (one repeat test allowed).

- Gilbert's syndrome.

- Positive screening test for HIV antibody, Hepatitis B surface antigen or Hepatitis C
antibody.

- Abnormal screening ECG: including machine-read QTc >450 msec (confirmed by manual
over read), QRS >110 msec, intermittent bundle branch block, frequent premature
atrial or premature ventricular contractions, or any rhythm other than normal sinus
rhythm which is interpreted by the Investigator to be clinically significant.

- History of sensitivity to a similar study drug (e.g., Karo Bio KB2115 or Metabasis
MB7811), or a history of important drug or other allergy (except for untreated,
asymptomatic seasonal allergies at time of dosing) unless deemed not clinically
significant by the Investigator.

- History of sensitivity to thyroid medication.

- History of intolerance to or adverse reaction to a statin, or history of myopathy
including rhabdomyolysis.

- Intolerance to beta-blockers (beta-blocker treatment could be appropriate to
alleviate tachycardia if observed).

- Participation in another clinical trial of an investigational drug (or medical
device) within the last 30 days prior to the first dosing day, or who have been
exposed to more than four new chemical entities within 12 months prior to the first
dosing day.

- Use of St. John's Wort within 28 days before the first dose of study drug.

- Unwilling to forgo consumption of red wine, Seville oranges, grapefruit or grapefruit
juice and/or pomelos, star fruit, grapefruit hybrids or other citrus juices from 5
days prior to the first dose of study drug and throughout the study.

- Subjects with a history of drug or alcohol abuse as defined by the Diagnostic and
Statistical Manual 5th Edition.

- History of regular alcohol consumption exceeding 7 drinks/week for females or 14
drinks/week for men (1 drink = 5 ounces of wine or 12 ounces of beer or 1.5 ounces of
hard liquor) within 6 months prior to screening.

- Use of acetaminophen within 7 days before dosing and throughout the study except for
the treatment of an adverse event as directed by the Investigator.

- History of regular use of tobacco or nicotine containing products within the past 6
months relative to screening.

- Positive urine drug screen or alcohol test at screening or Day -1.

- Women who are pregnant or may become pregnant, or are nursing.

- Strenuous physical activity which could cause muscle aches or injury, including
contact sports, at any time from 3 days prior to first dose of study drug until
completion of the study.

- Excessive caffeine intake (>3 cups of coffee/day or equivalent).