Echothiophate Iodide for the Prevention of Progression of Myopia
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 9 - 15 |
| Updated: | 4/21/2016 |
| Start Date: | June 2016 |
| End Date: | October 2017 |
| Contact: | Stephen A Mathias, MD,MPH |
| Email: | mdeyes@comcast.net |
| Phone: | 203-791-2020 |
The purpose of this study is to test the hypothesis that myopia progression can be slowed or
prevented by low dose Echothiophate Iodide.
prevented by low dose Echothiophate Iodide.
This pilot study is designed to establish proof of concept of a method to either slow or
stop the progression of myopia in children between the ages of 8 and 15 years by using
Echothiophate Iodide eye drops to alter the relationship between focusing (accommodation),
eye alignment, and peripheral blurring. Echothiophate Iodide 0.03% eye drops have been used
for years for the treatment of accommodative esotropia in children. A prospective double
blind randomized study of 33 children with active development of myopia will be divided into
a treatment group of 22 and a control group of 11. They will be treated for 18 weeks with
four planned visits at 6 week intervals. The progression of myopia will be measured by a
determination of the length of the eye (axial length measured by the IOL Master) and
cycloplegic refractions. Influencing factors such as corneal changes, lens changes and
macular choroidal thickness will be monitored for any significance. If successful, a larger
and longer study to slow the rate of myopia with echothiophate iodide will be done in order
to decrease the world's incidence of myopia currently at 25-33% in western countries and 85%
in Asian countries. This would also reduce the financial burden of glasses and contact
lenses as well as decrease the incidence of pathological eye disease due to high myopia.
stop the progression of myopia in children between the ages of 8 and 15 years by using
Echothiophate Iodide eye drops to alter the relationship between focusing (accommodation),
eye alignment, and peripheral blurring. Echothiophate Iodide 0.03% eye drops have been used
for years for the treatment of accommodative esotropia in children. A prospective double
blind randomized study of 33 children with active development of myopia will be divided into
a treatment group of 22 and a control group of 11. They will be treated for 18 weeks with
four planned visits at 6 week intervals. The progression of myopia will be measured by a
determination of the length of the eye (axial length measured by the IOL Master) and
cycloplegic refractions. Influencing factors such as corneal changes, lens changes and
macular choroidal thickness will be monitored for any significance. If successful, a larger
and longer study to slow the rate of myopia with echothiophate iodide will be done in order
to decrease the world's incidence of myopia currently at 25-33% in western countries and 85%
in Asian countries. This would also reduce the financial burden of glasses and contact
lenses as well as decrease the incidence of pathological eye disease due to high myopia.
Inclusion Criteria:
- Healthy children between 8-15 years of age
- Documentation of progression of myopia within the 12 months prior to enrollment
- Written informed consent/Assent for the study
Exclusion Criteria:
- Any history of retinopathy of prematurity, glaucoma, cataracts, corneal disease,
uveitis, manifest strabismus, nystagmus or ocular trauma
- Any history of unstable asthma, diabetes, or juvenile idiopathic arthritis Asthma
must be stable for three months prior to enrollment if utilizing oral or inhaled
steroids
- Systemic muscarinic agents, steroids, or anticholinesterase agents.
- Benzalkonium chloride preservative allergy.
- Astigmatism >0.75D
- Anisometropia >1.50D
- Pregnancy or a positive pregnancy test at the screening visit.
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