Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Residual Schizophrenia



Status:Completed
Conditions:Schizophrenia
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 60
Updated:8/3/2018
Start Date:September 2015
End Date:July 21, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety and Tolerability of AVP-786 (Deuterated [d6]-Dextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) as an Adjunctive Treatment for Patients With Residual Schizophrenia.

The objectives of this 12-week study are to evaluate the efficacy, safety, and tolerability
of AVP-786 as an adjunctive treatment compared with placebo in patients with residual
schizophrenia.


Inclusion Criteria:

- Patients who meet DSM-IV-TR diagnostic criteria for schizophrenia using the M.I.N.I.
version 6.0.

- Patients must meet PANSS criteria

- Patients currently receiving atypical antipsychotics are eligible provided they are on
a stable dose

Exclusion Criteria:

- Patients with current major depressive disorder (MDD)

- Patients with extrapyramidal syndrome secondary to their ongoing antipsychotic
medication

- Patients currently using anticholinergic medications

- Recent in-patient hospitalization
We found this trial at
17
sites
Clinical Trial Facility in Jamaica New York
Jamaica, New York 11432
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Jamaica, NY
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Atlanta, GA
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Clinical Trial Facility in Augusta Georgia
Augusta, Georgia 30912
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Augusta, GA
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
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from
Boston, MA
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Clinical Trial Facility in Cerritos California
Cerritos, California 90703
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from
Cerritos, CA
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
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from
Chicago, IL
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Clinical Trial Facility in Garden Grove California
Garden Grove, California
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Garden Grove, CA
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Clinical Trial Facility in Grand Rapids Michigan
Grand Rapids, Michigan 49503
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from
Grand Rapids, MI
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Clinical Trial Facility in Marlton New Jersey
Marlton, New Jersey 08053
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from
Marlton, NJ
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Clinical Trial Facility in National City California
National City, California 91950
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from
National City, CA
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Clinical Trial Facility in New York New York
New York, New York 10032
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from
New York, NY
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Clinical Trial Facility in Oakland California
Oakland, California 94612
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from
Oakland, CA
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Clinical Trial Facility in Orlando Florida
Orlando, Florida 32804
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from
Orlando, FL
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Clinical Trial Facility in Rochester New York
Rochester, New York
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from
Rochester, NY
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Clinical Trial Facility in San Diego California
San Diego, California
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San Diego, CA
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Clinical Trial Facility in Washington District of Columbia
Washington, District of Columbia
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from
Washington,
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Clinical Trial Facility in Worcester Massachusetts
Worcester, Massachusetts 01655
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from
Worcester, MA
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