Study of Intravenous RXDX-107 in Patients With Solid Tumors

Inclusion Criteria:

1. Confirmed relapsed or refractory locally advanced or metastatic solid cancer for whom
no standard therapy is considered appropriate, or for whom standard therapy is
considered intolerable.

2. >18 years of age.

3. ECOG performance status of 0 or 1.

4. Life expectancy of at least 3 months.

5. Received the last dose of previous treatment / therapy before Day 1 of cycle 1:

- 28 days for cytotoxic chemotherapy, immunotherapy, whole brain radiotherapy,
anticonvulsive therapy, stereotactic radiosurgery and major surgery

- 42 days for nitrosureas, mitomycin C, and liposomal anthracycline

- 14 days for non-cytotoxic cancer therapies and radiotherapy

6. Recovered from all toxic effects (excluding alopecia) of any prior anti-cancer therapy
to Grade ≤ 1 or to the baseline laboratory values.

7. Adequate organ function and baseline laboratory values

8. Women of childbearing potential must have a negative serum pregnancy

Phase 1b: Patient must have measurable disease

Exclusion Criteria:

1. Receiving other experimental therapy

2. Known symptomatic brain mets or leptomeningeal involvement

3. Myocardial infarction in the previous 12 weeks. Active ischemia or any other
uncontrolled cardiac condition such as angina pectoris, significant cardiac arrhythmia
requiring therapy, uncontrolled hypertension, or CHF.

4. Another concurrent illness which would preclude study conduct and assessment,
uncontrolled: medical condition, active infection, risk of bleeding, diabetes
mellitus, or pulmonary disease, or alcoholic liver disease, or primary biliary
cirrhosis.

5. Malignancy within 3 years or active disease requiring treatment other than the target
cancer. The exceptions are prostate cancer (Gleason grade < 6 with normalized PSA
levels), treated in situ cervical, breast carcinoma, squamous or basal cell skin
cancer.

6. Any condition that may compromise the ability to give written informed consent or to
comply with the study protocol.