PAI-1 Expression in Non-scarring Hair Loss
| Status: | Recruiting |
|---|---|
| Conditions: | Dermatology, Dermatology, Hair Loss |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 1/24/2018 |
| Start Date: | July 2015 |
| End Date: | June 2019 |
| Contact: | Yasmeen Ali |
| Email: | yasmeen.ali@northwestern.edu |
| Phone: | 312-503-5906 |
Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.
This study will investigate whether subjects who suffer from hair loss have increased levels
of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be
determined in subjects without hair loss and in subjects with non-scarring hair loss,
including androgenetic alopecia, telogen effluvium and alopecia areata.
of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be
determined in subjects without hair loss and in subjects with non-scarring hair loss,
including androgenetic alopecia, telogen effluvium and alopecia areata.
This study will compare the levels of PAI-1 expression in subjects with different forms of
non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss
subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty
Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All
subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin
biopsies will be determined by immunohistochemical staining. Samples will be kept for
approximately 15 years, after which time unused samples will be destroyed.
non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss
subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty
Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All
subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin
biopsies will be determined by immunohistochemical staining. Samples will be kept for
approximately 15 years, after which time unused samples will be destroyed.
Inclusion Criteria:
- Age-matched control subjects who do not have a history of hair loss
- A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium,
alopecia areata or normal scalp skin
- All subjects must have given signed, informed consent prior to registration in study
Exclusion Criteria:
- History of previous hair transplantation
- Current and past use of medications topically on the scalp
- Clinical or pathologic diagnosis of a scarring alopecia
- History of inflammatory conditions of the scalp such as psoriasis
We found this trial at
1
site
Chicago, Illinois 60611
Principal Investigator: Maria Colavincenzo, MD
Phone: 312-503-5906
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