Exercise in Genetic Cardiovascular Conditions



Status:Recruiting
Conditions:High Cholesterol, Cardiology, Cardiology, Orthopedic
Therapuetic Areas:Cardiology / Vascular Diseases, Orthopedics / Podiatry
Healthy:No
Age Range:8 - 60
Updated:10/20/2017
Start Date:May 2015
End Date:May 2020
Contact:Theresa Donovan, BS
Email:theresa.donovan@yale.edu
Phone:866-207-9813

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Trial Summary
Trial Overview
Inclusion Criteria

Exercise in Genetic Cardiovascular Conditions (Lifestyle and Exercise in Hypertrophic Cardiomyopathy "LIVE-HCM"/Lifestyle and Exercise in the Long QT Syndrome "LIVE-LQTS"

The goal is to determine how lifestyle and exercise impact the well-being of individuals with
hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS).

Yale is the central site for this multicenter study. Patients with HCM and LQTS will be
recruited via high-volume HCM and LQTS sites, patient-groups, and websites. Information about
exercise participation will be acquired via interview and online instruments at enrollment
and every six months for three years. Quality of Life questionnaires will be filled out at
enrollment and at the end of the study. Participants will receive a Fitbit (pedometer) and
will wear it initially for two weeks and then one week every three months. The Fitbit is used
for assessment of exercise level only. Clinical records will be obtained from treating
physicians. Participants will also be asked to call the central site if they experience
syncope, appropriate ICD (implantable cardioverter defibrillator) shock, or resuscitated
arrest. Information regarding the patient's activity at the time of event will then be
obtained by phone interview. Follow-up clinical records will be obtained as indicated to
corroborate endpoints.

Inclusion Criteria:

- Individuals with Hypertrophic Cardiomyopathy or Long QT Syndrome

Exclusion Criteria:

- Individuals with Hypertrophic Cardiomyopathy with systolic or diastolic heart failure
which precludes vigorous exercise will not be enrolled (NYHA III/IV)
We found this trial at
33
sites
Brigham and Women's
Boston, Massachusetts 02115
Principal Investigator: Carolyn Ho, MD
Phone: 617-525-7168
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Boston, MA
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Cleveland Clinic
9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Principal Investigator: Peter F Aziz, MD, FHRS
Phone: 216-444-7932
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Cleveland, OH
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Indiana University
425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Principal Investigator: Michael Emery, MD
Phone: 317-274-0985
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Indianapolis, IN
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University of Iowa
101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
Principal Investigator: Ian Law, MD
Phone: 319-356-3537
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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University of Pittsburgh
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Principal Investigator: Timothy Wong, MD
Phone: 412-647-3611
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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Univ of Washington
Seattle, Washington 98104
(206) 543-2100
Principal Investigator: David Owens, MD
Phone: 206-221-7594
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Stanford
Stanford, California 94304
Principal Investigator: Euan Ashley, MD
Phone: 650-736-6982
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Stanford, CA
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University of Michigan
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Sharlene Day, MD
University of Michigan The University of Michigan was founded in 1817 as one of the...
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Johns Hopkins
Baltimore, Maryland 21218
(410) 516-8000
Principal Investigator: Gordon Tomaselli, MD
Phone: 410-502-2578
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Tufts
Boston, Massachusetts 02111
Principal Investigator: Martin Maron, MD
Phone: 617-636-5000
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Boston, MA
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Boston Children's
Boston, Massachusetts 02210
Principal Investigator: Steve Colan, MD
Phone: 857-218-3628
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Royal Prince Alfred Hospital/Sydney AU
Camperdown, New South Wales 2050
Principal Investigator: Christopher Semsarian, MD
Phone: +61 2 9565 6195
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Lurie Children's
Chicago, Illinois 60611
Principal Investigator: Greg Webster, MD
Phone: 312-227-1549
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Cincinnati Children's
Cincinnati, Ohio 45229
Principal Investigator: Richard Coszek, MD
Phone: 513-803-9003
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UT Southwestern
Dallas, Texas 75390
Principal Investigator: Aslan Turer, MD
Phone: 214-645-7083
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Texas Children's
Houston, Texas 77030
Principal Investigator: Silvana Molossi, MD
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Cedar Sinai/LA Cardiology
Los Angeles, California 90017
Principal Investigator: David Cannom, MD
Phone: 213-977-4176
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Los Angeles, CA
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University of Louisville
500 S Preston St
Louisville, Kentucky
(502) 852-5555
Principal Investigator: Janice sullivan, MD
Phone: 502-629-2721
University of Louisville The University of Louisville is a state supported research university located in...
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University of Tennessee Health Science Center/Le Bonheur
Memphis, Tennessee 38103
Principal Investigator: Jeffrey Towbin, MD
Phone: 901-287-6380
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Miami Children's (Nicklaus Children's Hospital)
Miami, Florida 33155
Principal Investigator: Ronald Kanter, MD
Phone: 786-624-2590
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Vanderbilt University
2201 West End Ave
Nashville, Tennessee 37232
(615) 322-7311
Principal Investigator: Prince Kannankeril, MD
Phone: 615-343-6503
Vanderbilt University Vanderbilt offers undergraduate programs in the liberal arts and sciences, engineering, music, education...
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Yale University
New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Rachel Lampert, MD
Phone: 866-207-9813
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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NYU
New York, New York
Principal Investigator: Marina Cerrone, MD
Phone: 212-263-9136
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Children's Omaha
Omaha, Nebraska 68114
Principal Investigator: Christopher Erickson, MD
Phone: 402-955-4350
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Omaha, NE
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The University of California Irvine
Orange, California 92868
Principal Investigator: Anjan Batra, MD
Phone: 714-509-8735
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The Children's Hospital of Philadelphia (CHOP)
Philadelphia, Pennsylvania 19104
Principal Investigator: Mually Shah, MD
Phone: 267-426-9820
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Oregon Health & Science
Portland, Oregon 97239
Principal Investigator: Stephen Heitner, MD
Phone: 503-494-1775
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Portland, OR
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The Mayo Clinic
Rochester, Minnesota 55905
Principal Investigator: Michael J. Ackerman, M.D., Ph.D.
Phone: 507-284-8900
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University of Utah (Primary Children's)
Salt Lake City, Utah 84113
Principal Investigator: Susan Etheridge, MD
Phone: 801-587-9011
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University California San Diego - Rady's Children's Hospital
San Diego, California
Principal Investigator: James Perry, MD
Phone: 858-576-1700
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Seattle Children's
Seattle, Washington 98115
Principal Investigator: Jack Salerno, MD
Phone: 206-987-7173
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University of Arizona
Tucson, Arizona 85721
(520) 621-2211
Principal Investigator: Jil Tardif, MD
Phone: 520-626-5431
University of Arizona The University of Arizona is a premier, public research university. Established in...
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Children's National
111 Michigan Avenue Northwest
Washington, D.C., District of Columbia 20010
Principal Investigator: Charles Berul, MD
Phone: 202-476-4970
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