Treatment of Chronic Stroke With IpsiHand
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 88 |
| Updated: | 9/19/2018 |
| Start Date: | August 2012 |
| End Date: | November 30, 2015 |
A Brain Computer Interface and Brain-Controlled Stroke Rehabilitation Method Utilizing Electroencephalography in Hemiparetic and Hemiplegic Stroke Patients to Achieve Thought Control of Machines and a Better Understanding of Brain Function
The ultimate goal of this project is to develop a functioning and clinically feasible method
for restoring function to motor-impaired stroke survivors. This ultimate goal will be
approached through two different means. The first method is to develop a functioning
brain-computer interface that operates based on cortical activity ipsilateral to an intended
movement on the motor-impaired side of the body. And secondly, to develop new methods of
rehabilitation that involve stimulating peripheral muscles based upon cortical activity
ipsilateral to intended movements. Finally, the study seeks to assess changes in functional
connectivity as a result of using a BCI device.
for restoring function to motor-impaired stroke survivors. This ultimate goal will be
approached through two different means. The first method is to develop a functioning
brain-computer interface that operates based on cortical activity ipsilateral to an intended
movement on the motor-impaired side of the body. And secondly, to develop new methods of
rehabilitation that involve stimulating peripheral muscles based upon cortical activity
ipsilateral to intended movements. Finally, the study seeks to assess changes in functional
connectivity as a result of using a BCI device.
This study will be carried out in two phases designed to achieve the objectives described
above. The first phase will determine the feasibility of recording ipsilateral
(contralesional) motor commands and use the signals to control a computer. This phase will
involve recording EEG signals during the performance of real and imagined motor movements of
both the impaired and non-impaired hand in stroke survivors. After recording the signals and
analyzing the data, the signals will be used to try to control a cursor on a computer screen
or a robotic hand. The second phase of the study will determine if the BCI system can be used
to impact rehabilitation. Motor commands would be performed as in phase 1 to determine the
accompanying EEG signals. The EEG signals would then be used to control stimulation of the
impaired limb. Rehabilitation would be assessed by examining changes in commonly used
functional motor scores.
The ultimate goal of this project is to develop a functioning and clinically feasible method
for restoring function to motor-impaired stroke survivors. This ultimate goal will be
approached through two different means. The first method is to develop a functioning
brain-computer interface that operates based on cortical activity ipsilateral to an intended
movement on the motor-impaired side of the body. And secondly, to develop new methods of
rehabilitation that involve stimulating peripheral muscles based upon cortical activity
ipsilateral to intended movements. Finally, the study seeks to assess changes in functional
connectivity as a result of using a BCI device.
above. The first phase will determine the feasibility of recording ipsilateral
(contralesional) motor commands and use the signals to control a computer. This phase will
involve recording EEG signals during the performance of real and imagined motor movements of
both the impaired and non-impaired hand in stroke survivors. After recording the signals and
analyzing the data, the signals will be used to try to control a cursor on a computer screen
or a robotic hand. The second phase of the study will determine if the BCI system can be used
to impact rehabilitation. Motor commands would be performed as in phase 1 to determine the
accompanying EEG signals. The EEG signals would then be used to control stimulation of the
impaired limb. Rehabilitation would be assessed by examining changes in commonly used
functional motor scores.
The ultimate goal of this project is to develop a functioning and clinically feasible method
for restoring function to motor-impaired stroke survivors. This ultimate goal will be
approached through two different means. The first method is to develop a functioning
brain-computer interface that operates based on cortical activity ipsilateral to an intended
movement on the motor-impaired side of the body. And secondly, to develop new methods of
rehabilitation that involve stimulating peripheral muscles based upon cortical activity
ipsilateral to intended movements. Finally, the study seeks to assess changes in functional
connectivity as a result of using a BCI device.
Inclusion Criteria:
- 6 months post stroke
- Modified Ashworth Scale of 1+ or less of elbow flexion in the affected upper extremity
- Short Blessed Test Score of 8 or less
- Unstructured Mesulam with 2 or less omissions
Exclusion Criteria:
- Dementia
- Severe spasticity in affected upper extremity
- Unilateral Visual Inattention (neglect)
- Contracture(s) in the affected upper extremity
- Botox injections administered within 9 months
- Aphasia which limits effective communication
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Thy Huskey, MD
Phone: 314-585-5726
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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