Gabapentin in Patients at Clinical Risk for Psychosis

Inclusion Criteria:

1. COPE patient between age of 18-30

2. Capacity to give informed consent

3. Currently using a reliable method of birth control (female) (condom plus spermicide,
diaphragm plus spermicide, IUD, birth control pills, norplant, vasctomy in partner)

Exclusion Criteria:

1. Metal implants in body or a history of metal working, or more than one past MRI scan
with gadolinium

2. Lifetime diagnosis of asthmatic symptoms within the past 3 years or known sensitivity
to contrast agents

3. Lifetime diagnosis of renal failure/disease

4. Acute neurological, neuroendocrine,or medical disorder including renal insufficiency

5. Lifetime diagnosis of hypertension or diabetes

6. Intelligence Quotient (IQ) < 70

7. Acute risk for suicide and/or violence

8. Pregnant, lactating

9. Current abuse of substances (alcohol, cocaine, stimulants, cannabis, opiates,
sedative hypnotics)

10. Current use or anticipated need for antipsychotics or mood stabilizers (all
antipsychotics, also Depakote, lithium, lamotrigine, pregabalin or any med with a
mechanism of action like gabapentin)

11. The Clinical Global Impressions Scale (CGI)-improvement score during study equal to
or greater than 6