Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain, Orthopedic |
| Therapuetic Areas: | Musculoskeletal, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 10 - 18 |
| Updated: | 1/26/2019 |
| Start Date: | May 1, 2016 |
| End Date: | April 1, 2020 |
| Contact: | Keri Hainsworth, PhD |
| Email: | khainsworth@chw.org |
| Phone: | 414266-6306 |
Acute pain management following major surgical procedures in pediatric patients continues to
be a challenge, especially after extensive posterior spine fusions.
Spine surgery is particularly traumatic, initiating pain in both peripheral and central
pathways. While the standard management of post-surgical pain involves a multimodal approach,
opioids provide the predominant benefit. However, opioid use is associated with many adverse
effects, including nausea, constipation, and pruritus. Perioperative methadone may decrease
total opioid consumption and adverse effects as well as improve satisfaction with pain
management after scoliosis repair.
be a challenge, especially after extensive posterior spine fusions.
Spine surgery is particularly traumatic, initiating pain in both peripheral and central
pathways. While the standard management of post-surgical pain involves a multimodal approach,
opioids provide the predominant benefit. However, opioid use is associated with many adverse
effects, including nausea, constipation, and pruritus. Perioperative methadone may decrease
total opioid consumption and adverse effects as well as improve satisfaction with pain
management after scoliosis repair.
This study is a double blind comparison, evaluating the benefits of intraoperative methadone
in extensive posterior spine fusion surgery for idiopathic scoliosis. Methadone 0.2 mg/kg
will be given to the treatment group. Postoperative evaluation for narcotic use, pain
control, and adverse effects will be compared to a standard treatment approach used at
Children's Hospital of Wisconsin.
in extensive posterior spine fusion surgery for idiopathic scoliosis. Methadone 0.2 mg/kg
will be given to the treatment group. Postoperative evaluation for narcotic use, pain
control, and adverse effects will be compared to a standard treatment approach used at
Children's Hospital of Wisconsin.
Inclusion Criteria:
- Age 10-18 years
- Idiopathic scoliosis
- Fusion levels planned for 10 or greater
- English speaking
- American Society of Anesthesiology (ASA) class 1 - 3
Exclusion Criteria:
- Current narcotic use / History of substance abuse
- Morphine, hydromorphone or methadone allergies
- Pregnancy
- Seizure Disorders
- Bleeding disorders
- Non-English speaking
We found this trial at
1
site
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 266-2000
Phone: 414-266-3561
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