Gut Microbiota And Radiotherapy

Inclusion Criteria:

- Patient is planned to receive Stereotactic Body Radiotherapy (SBRT) to a lung lesion
(either presumed or biopsy-proven NSCLC

- Age 18 years old or older

- Patient capable of giving informed consent

Exclusion Criteria

- Use of antibiotics, antifungal, antivirals or antiparasitics during the 4 weeks prior
to registration

- Active infection with oral temperature >100°F

- Use of corticosteroids, methotrexate or immunosuppressive drugs during the 4 weeks
prior to registration

- Use of chemotherapy during the 4 weeks prior to radiotherapy or during radiotherapy.
Chemotherapy cannot begin before the collection of the 30-day post treatment sample
(S4).

- Confirmed or suspected HIV, HBV or HCV

- Chronic constipation (bowel movements less frequent than every other day)

- Active uncontrolled gastrointestinal disorders such as inflammatory bowel disease,
moderate/severe irritable bowel syndrome, persistent, infectious gastroenteritis,
colitis or gastritis, persistent or chronic diarrhea of unknown etiology, Clostridium
Difficile infection (recurrent) or Helicobacter Pylori infection (untreated)

- Major surgery of the GI tract, with the exception of cholecystectomy and
appendectomy, in the past five years. Any major bowel resection at any time

- Patients on anti-diarrheal medications

- Patients on probiotics