Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation

Inclusion Criteria:

- brain lesions, including but not limited to tumors, epileptic foci, and vascular
abnormalities, in or around eloquent brain regions (i.e., motor, language);

- clinical need for pre-operative 'advanced imaging' (which includes conventional DTI);

- age between 18-80 years of age;

- male or female gender. Eloquent regions include: Temporal and frontal lobes
(speech/language); bilateral occipital lobes (vision); bilateral parietal lobes
(sensation); and bilateral motor cortex (movement).

Exclusion Criteria:

- a contraindication for obtaining an MRI scan (e.g. implanted devices, retrained
foreign body)

- pregnancy

- absence of the capacity to make medical decisions or provide informed consent.