Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 10/7/2018 |
| Start Date: | October 2015 |
| End Date: | August 2020 |
| Contact: | Melanie Jefferson, MS |
| Email: | melanie.l.jefferson@emory.edu |
| Phone: | 404-321-6111 |
Post-Traumatic Stress Disorder and Cardiovascular Disease Risk: Role of Sympathetic Overactivity and Angiotensin II
The purpose of this study is to find out why patients with post-traumatic stress disorder
(PTSD) have an increased risk for heart disease and high blood pressure later in life. A
second purpose is to find out what causes PTSD patients to have high adrenaline levels during
stress. This study will also test if a medicine called losartan improves high adrenaline
levels in patients with PTSD and if a certain gene that has to do with high blood pressure
might be associated with high adrenaline levels.
(PTSD) have an increased risk for heart disease and high blood pressure later in life. A
second purpose is to find out what causes PTSD patients to have high adrenaline levels during
stress. This study will also test if a medicine called losartan improves high adrenaline
levels in patients with PTSD and if a certain gene that has to do with high blood pressure
might be associated with high adrenaline levels.
Inclusion Criteria:
- veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age,
gender, and race.
Exclusion Criteria:
- pregnancy
- hypertension
- diabetes
- heart or vascular disease
- illicit drug use
- excessive alcohol use (>2 drinks per day)
- hyperlipidemia
- autonomic dysfunction
- current treatment with clonidine, beta blockers, angiotensin-converting-enzyme (ACE)
inhibitors, or angiotensin II receptor blockers (ARBs)
- treatment with monoamine oxidase (MAO) inhibitors within the last 14 days
- any serious systemic disease
- chronic kidney disease defined as estimated glomerular filtration rate (GFR) < 60
cc/min
- hyperkalemia (serum potassium > 5 meq/dL)
- systolic blood pressure < 100 mm Hg
- diastolic blood pressure < 60 mm Hg
- heart rate < 50 beats/min
- known hypersensitivity to ARBs or beta blockers
We found this trial at
1
site
Decatur, Georgia 30033
Principal Investigator: Jeanie Park, MD
Phone: 404-321-6111
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