A Study of Ramucirumab (LY3009806) in Children With Refractory Solid Tumors



Status:Recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 21
Updated:4/5/2019
Start Date:December 11, 2015
End Date:March 1, 2020
Contact:There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
Phone:1-317-615-4559

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1 Study Of Ramucirumab, a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 (VEGFR-2) Receptor in Children With Refractory Solid Tumors, Including CNS Tumors

The main purpose of this study is to evaluate the safety of the study drug known as
ramucirumab in children with recurrent or refractory solid tumors including central nervous
system (CNS) tumors.


Inclusion Criteria:

- Part A: participants with recurrent or refractory non-CNS solid tumors

- Part B: participants with recurrent or refractory CNS tumors

- Measurable or evaluable disease

- No other therapeutic options

- Performance Status: Karnofsky ≥50% for participants >16 years and Lansky ≥50 for
participants ≤16 years

Exclusion Criteria:

- Active or recent history of serious bleeding events

- Active or recent history of gastrointestinal perforations, ulcers, fistulas or
abscesses

- Active or recent history of hypertensive crisis or hypertensive encephalopathy

- Active non-healing wound or bone fracture

- History of solid organ transplant
We found this trial at
21
sites
University of Minnesota Hospital
Minneapolis, Minnesota 55455
Principal Investigator: Emily Greengard
Phone: 612-626-2378
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Children's Hospital of Alabama
1600 7th Avenue
Birmingham, Alabama 35233
(205) 638-9100
Principal Investigator: Gregory Friedman
Phone: 205-638-9285
Children's Hospital of Alabama Children
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Birmingham, AL
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St. Jude Children's Research Hospital
262 Danny Thomas Pl
Memphis, Tennessee 38105
(901) 495-3300
Principal Investigator: Wayne L Furman
Phone: 901-595-2403
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
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Memphis, TN
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Children's Hospital of Orange County
1201 W La Veta Ave
Orange, California 92868
(714) 997-3000
Principal Investigator: Josephine HaDuong
Phone: 714-532-8629
Children's Hospital of Orange County For more than 45 years, CHOC Children’s has been steadfastly...
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Orange, CA
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Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Principal Investigator: Elizabeth Fox
Phone: 267-425-3010
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Philadelphia, PA
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Principal Investigator: Suman Malempati
Phone: 503-494-1543
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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University of Michigan Health Systems
Ann Arbor, Michigan 48109
Principal Investigator: Rajen J Mody
Phone: 734-764-7126
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Ann Arbor, MI
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Children's Healthcare of Atlanta @ Scottish Rite
Atlanta, Georgia 30342
Principal Investigator: Jason Fangusaro
Phone: 404-727-1180
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Atlanta, GA
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Mark O Harfield-Warren Grant Magnuson Clinical Center
Bethesda, Maryland 20892
Principal Investigator: Brigitte Widemann
Phone: 301-496-7387
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Bethesda, MD
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Ann & Robert H. Lurie Children's Hospital of Chicago
225 E Chicago Ave
Chicago, Illinois 60611
(312) 227-4000
Principal Investigator: Stewart Goldman
Phone: 312-227-4844
Ann & Robert H. Lurie Children's Hospital of Chicago Ann & Robert H. Lurie Children
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Chicago, IL
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Children's Hospital Medical Center
Cincinnati, Ohio 45229
Principal Investigator: James Geller
Phone: 513-636-6090
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Cincinnati, OH
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Texas Children's Hospital
6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Principal Investigator: Jodi Muscal
Phone: 832-824-4632
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
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Houston, TX
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Riley Hosptial for Children
Indianapolis, Indiana 46202
Principal Investigator: James Croop
Phone: 317-944-8784
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Indianapolis, IN
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Medical College of Wisconsin
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Principal Investigator: Paul Harker-Murray
Phone: 414-456-8131
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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Milwaukee, WI
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Children's Oncology Group
Monrovia, California 91016
Principal Investigator: SMO Children's Oncology Group
Phone: 626-241-1630
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Monrovia, CA
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Principal Investigator: Alice Lee
Phone: 212-305-5808
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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New York, NY
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Children's Hospital of Pittsburgh
3414 Fifth Avenue
Pittsburgh, Pennsylvania 15213
Principal Investigator: Jean M Tersak
Phone: 412-692-5055
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Pittsburgh, PA
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Washington University Medical School
Saint Louis, Missouri 63110
Principal Investigator: Robert Hayashi
Phone: 314-362-7229
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Saint Louis, MO
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University of California at San Francisco
San Francisco, California 94143
Principal Investigator: Kieuhoa Vo
Phone: 415-476-3831
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San Francisco, CA
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Seattle Children's Hospital, Research, and Foundation
Seattle, Washington 98105
Principal Investigator: Julie Park
Phone: 206-907-2106
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Seattle, WA
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Childrens National Medical Center
111 Michigan Ave NW
Washington, District of Columbia
(202) 476-5000
Principal Investigator: AeRang Kim
Phone: 202-476-4744
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
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Washington,
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