A Study of Hypoxia-inducible Factor 1a (HIF1A) Messenger Ribonucleic Acid (mRNA) Antagonist (RO7070179), to Demonstrate Proof-of-mechanism in Adult Participants With Hepatocellular Carcinoma (HCC)

Inclusion Criteria:

- Male or female of >=18 years of age with the Eastern Cooperative Oncology Group (ECOG)
performance status 0-1, Child-Pugh score of 5-7, and Life expectancy of 3 months or
greater.

- Confirmed to have HCC as described by the American Association for the Study of Liver
Disease (AASLD).

- Participants who have failed at least one line of systemic therapy for advanced stage
HCC or participants who are ineligible or unable to tolerate the standard of care
treatment.

- Have measurable or evaluable disease.

- Participants with normal major organ functions as defined by hemoglobin (HgB) >= 8.5
gram/decilitre (dL), absolute neutrophil count (ANC) >= 1000/microliter (mcL),
platelet >= 60,000/micL, aspartate aminotransferase/alanine transaminase (AST/ALT) <=
3 x Upper Limit of Normal (ULN), total Bilirubin <= 2 x ULN, creatinine <= 2 x ULN.

- Willingness to undergo two tumor biopsies: before and after administration of
RO7070179.

Exclusion Criteria:

- Concurrent serious medical illness that could potentially interfere with protocol
compliance (such medical illness will not include hepatitis or cirrhosis, as the
degree of liver impairment caused by these diseases are covered by other exclusion
criteria).

- Active hepatitis B or C, but participants on stable medications for hepatitis B or C.

- Bleeding esophageal or gastric varices within 2 months before enrollment.

- Participants who need to take therapeutic anti-coagulation or anti-platelet therapy.

- Presence of ascites that preclude biopsy of liver lesions.

- History of unstable angina or myocardial infarction within 12 months prior to Day 1 or
ischemic heart disease.

- Known HIV positive and positive screening pregnancy test or is breast-feeding.

- Female or male of reproductive capacity unwilling to use methods of contraception to
prevent pregnancy during this study. Participants unwilling to use methods of
contraception to prevent pregnancy for 6 months after the last dose of RO7070179 due
to the potential for prolonged half-life of RO7070179 in the liver.

- Known, clinically suspected, or history of CNS tumor involvement.

- Prior chemotherapy, immunotherapy, investigational therapeutic agent, or other therapy
used to treat HCC within 4 weeks before the first scheduled administration of
RO7070179.

- Participants who have not recovered from any reversible side effects (except alopecia)
to Grade 0 or 1 toxicity attributed to the administration of an investigational
therapeutic agent, chemotherapy, immunotherapy, radiotherapy, or other agents
previously used to treat the cancer.

- Any condition that, in the opinion of the investigator or the Sponsor, makes the
patients unsuitable for the study.

- Inability to comply with the study protocol.