Study of Structural Imaging
| Status: | Suspended |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 30 - 60 |
| Updated: | 4/6/2019 |
| Start Date: | September 30, 2015 |
| End Date: | September 30, 2020 |
Cross-Sectional and Longitudinal Study of Structural Imaging
Background:
The way alcohol affects brain structure has been widely studied. But the way it affects all
parts of the brain is still unknown. Researchers want to use magnetic resonance imaging (MRI)
scans to study brain structure and function. They hope this will help them better understand
changes that happen in brain regions during treatment of alcohol use disorders.
Objectives:
To study changes in the brain by using MRI in people with and without alcohol use disorders.
To study how brain changes affect gait, balance, cognitive ability, and behavior. To see how
the brain recovers when alcohol use stops.
Eligibility:
People with alcohol dependence who are currently hospitalized in a particular unit at NIH.
Healthy volunteers 30 60 years old without an alcohol use disorder.
Design:
Participants will be screened under a separate protocol.
Participants will give a urine sample for a drug test and pregnancy test at each study visit.
They will also have to pass a breath alcohol test.
At the first visit, participants will have an MRI. The scanner is a metal cylinder in a
strong magnetic field. Participants will lie on a table that slides in and out of the
cylinder.
They will do behavior and memory tasks outside the scanner.
They will have gait and balance tested. They will have to stand on both legs, stand on just
one leg, and walk in a straight line. They will perform each task with eyes open, then with
eyes closed.
They will have tests of memory, thinking, and problem solving.
Some participants will have a second visit. They will have another MRI and repeat some of the
behavior and memory tasks.
The way alcohol affects brain structure has been widely studied. But the way it affects all
parts of the brain is still unknown. Researchers want to use magnetic resonance imaging (MRI)
scans to study brain structure and function. They hope this will help them better understand
changes that happen in brain regions during treatment of alcohol use disorders.
Objectives:
To study changes in the brain by using MRI in people with and without alcohol use disorders.
To study how brain changes affect gait, balance, cognitive ability, and behavior. To see how
the brain recovers when alcohol use stops.
Eligibility:
People with alcohol dependence who are currently hospitalized in a particular unit at NIH.
Healthy volunteers 30 60 years old without an alcohol use disorder.
Design:
Participants will be screened under a separate protocol.
Participants will give a urine sample for a drug test and pregnancy test at each study visit.
They will also have to pass a breath alcohol test.
At the first visit, participants will have an MRI. The scanner is a metal cylinder in a
strong magnetic field. Participants will lie on a table that slides in and out of the
cylinder.
They will do behavior and memory tasks outside the scanner.
They will have gait and balance tested. They will have to stand on both legs, stand on just
one leg, and walk in a straight line. They will perform each task with eyes open, then with
eyes closed.
They will have tests of memory, thinking, and problem solving.
Some participants will have a second visit. They will have another MRI and repeat some of the
behavior and memory tasks.
Objective
The purpose of this protocol is to characterize cerebellar volumes and function in alcoholics
and recovery of cerebellar volume and function during early abstinence. This study also
investigates how cerebrocerebellar circuits contribute to cognitive and motor impairment in
alcoholism.
Study Population
Healthy volunteers and Inpatient participants with alcohol use disorders.
Design
Participants will receive whole-brain structural imaging and assessment of cerebellar
function at the time of admission and again at the time of discharge.
Outcome
The Primary outcome of this study is to assess recovery of cerebellar structure and function
at the end of treatment compared to treatment entry measures.
The purpose of this protocol is to characterize cerebellar volumes and function in alcoholics
and recovery of cerebellar volume and function during early abstinence. This study also
investigates how cerebrocerebellar circuits contribute to cognitive and motor impairment in
alcoholism.
Study Population
Healthy volunteers and Inpatient participants with alcohol use disorders.
Design
Participants will receive whole-brain structural imaging and assessment of cerebellar
function at the time of admission and again at the time of discharge.
Outcome
The Primary outcome of this study is to assess recovery of cerebellar structure and function
at the end of treatment compared to treatment entry measures.
- INCLUSION CRITERIA:
1. 30 to 60 years old
2. Physically healthy
3. Healthy volunteers only: Currently consuming 7 or less standard drinks per week
if female; 14 or less drinks per week if male.
EXCLUSION CRITERIA:
1. Significant history of head trauma or cranial surgery,
2. History of diabetes or stroke which requires medical intervention,
3. Clinical or laboratory evidence of severe hepatic disease as determined by ALT or AST
greater than 5 times the upper normal limit, INR greater than 2.0, total bilirubin
greater than 2.5 mg/dL, and albumin lower than 3.0 g/dL.
4. Positive HIV test.
5. Healthy volunteers only: 5 or more binge drinking episodes in the past 30 days (5 or
more standard drinks on one occasion for males, 4 or more standard drinks on one
occasion for females within two hours)
6. Healthy volunteers only:
- Have fulfilled DSM-IV or DSM-5 criteria for current alcohol use disorder
- Have fulfilled DSM-IV or DSM-5 criteria for current substance use disorder
7. Presence of any ferromagnetic objects in the body that may be aversively affected by
MRI.
8. Uncomfortable in enclosed spaces (has claustrophobia) such that they would feel
discomfort in the scanner.
9. Female participants only: Are currently pregnant
10. Inpatient participants only: Currently experiencing symptoms of withdrawal from
alcohol (As determined by the most recent measurement within the past 30 days CIWA
score > 8)
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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