The Effects of Exercise of Secreted Factors From Muscle and Adipose Tissue
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 35 |
| Updated: | 4/21/2016 |
| Start Date: | October 2015 |
| End Date: | September 2016 |
| Contact: | Jeffrey Richard |
| Email: | exercise.research@joslin.harvard.edu |
| Phone: | 6173094134 |
Investigation of Exercise-Induced Myokines and Adipokines
The purpose of this study is to find out whether exercise leads to changes in the blood that
are produced by exercised muscles and if these changes produce new hormones that affect the
body's regulation of sugar and body weight.
are produced by exercised muscles and if these changes produce new hormones that affect the
body's regulation of sugar and body weight.
Recent work in the laboratory at the Joslin Diabetes Center and elsewhere has shown that
when small animals exercise they improve their muscles and improve their blood sugar levels.
Also, these animals show changes in their abdominal fat tissue, compared to animals that did
not exercise. Our data suggest that factors released from exercised muscle and fat tissue
from exercised mice also has a positive effect on other tissues in the same animal.
Therefore, there could be new factors or hormones, which come from the trained animals'
muscles or fat tissue and which exert a positive effect on the animals' blood sugar levels.
Large studies with human volunteers have shown that exercise can improve blood sugar uptake
into skeletal muscle and lower blood sugar levels, thereby preventing type 2 diabetes. The
purpose if this study is to evaluate if a single exercise bout leads to changes in
circulating factors in the blood. We plan to detect if there are hormones being produced in
the body that have a beneficial effect elsewhere in the body.
when small animals exercise they improve their muscles and improve their blood sugar levels.
Also, these animals show changes in their abdominal fat tissue, compared to animals that did
not exercise. Our data suggest that factors released from exercised muscle and fat tissue
from exercised mice also has a positive effect on other tissues in the same animal.
Therefore, there could be new factors or hormones, which come from the trained animals'
muscles or fat tissue and which exert a positive effect on the animals' blood sugar levels.
Large studies with human volunteers have shown that exercise can improve blood sugar uptake
into skeletal muscle and lower blood sugar levels, thereby preventing type 2 diabetes. The
purpose if this study is to evaluate if a single exercise bout leads to changes in
circulating factors in the blood. We plan to detect if there are hormones being produced in
the body that have a beneficial effect elsewhere in the body.
Inclusion Criteria:
- Age between 18-35. Body mass index (BMI) must be ≥20 and ≤26 kg/m2. HbA1c values ≤5.7%
Exclusion Criteria:
- Age <18 and >35; HbA1c ≥ 5.7%; heart or lung disease; acute systemic infection
accompanied by fever, body aches, or swollen lymph glands; BMI ≥ 26 kg/m2; current dieting
or weight loss efforts; current pregnancy or breastfeeding; known history of HIV/AIDS;
cancer; biochemical evidence of renal or hepatic dysfunction; renal or liver disease;
demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis; recent
blood donation; clinical history of stroke; hypertension (systolic > 140 mmHg or diastolic
> 90 mmHg); type 1 or 2 diabetes; history of keloid formation inability to exercise at 50%
of predicted heart rate (HR) reserve at baseline. Participants taking beta-blockers
Participants who screen positive for The American Heart Association's contraindications to
exercise testing
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