An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective

This study will evaluate the optimal dose of tofacitinib needed to achieve low disease
activity (LDA) or clinical remission as measured by the CDAI score. Once LDA or clinical
remission has been achieved, the structural benefit in reducing erosions, synovitis and bone
edema as measured by low field MRI will be determined at the same time period by the use of
the OMERACT/RAMRIS scoring system and correlated to the clinical findings. The target for
each patient will be determined at the time of study entry depending on the degree of
disease activity of the individual patient. This is based on the understanding that LDA is
an acceptable goal in certain patients with long standing disease or high disease activity.
If the patient reaches LDA while taking tofacitinib at a 5 mg b.i.d. dose, the patient will
be given the opportunity to have the dose increased to 10 mg b.i.d. in the hopes of reaching
clinical remission.

There are two treat to target goals: Clinical Remission as defined by a CDAI score of <2.8
for those patients who entered the study with a CDAI score of <22 and Low Disease Activity
(LDA) as defined by a CDAI score of <10 for those who entered the study with a CDAI score of
> 22.

Inclusion Criteria:

1. Patient must be at least 18 years old at the screening visit

2. Patient must be able to understand the information provided to them and give written
Informed Consent

3. Female subjects of childbearing potential must test negative for pregnancy

4. Male and female subjects of childbearing potential must agree to use two highly
effective methods of contraception throughout the study and for at least 3 months
after the last dose of tofacitinib.

5. Female patients who are not of childbearing potential must either be postmenopausal
for at least 12 months or have undergone a documented hysterectomy and/or bilateral
oophorectomy.

6. Patients can be naïve to biologic therapy or have had exposure to TNF or biologic
therapy (see appropriate wash out schedule) and be experiencing at least a moderate
disease activity score as determined by a CDAI of > 10 at Screening despite currently
receiving Methotrexate therapy at a dose of 10-25 mg/weekly for at least 12 weeks and
at a stable dose for the past 4 weeks.

7. Patients on prednisone must be receiving a daily dose of < 10 mg.

8. Subjects must screen negative for active tuberculosis (TB) by either a PPD or a
QuantiFERON Gold test (unless previously performed and documented within 3 months
prior to screening). If patient tests positive for latent TB at screening, the chest
X-ray at Screening must be negative for active TB and the patient must be started on
( or have completed) an adequate course of therapy for latent tuberculosis at the
Baseline visit. Patient must complete the entire 9 month course of treatment for
latent TB.

9. Chest radiograph taken at screening (unless taken and documented within 3 months
prior to screening) must be negative for active TB and have non clinically
significant medical findings.

10. Patients must be able and willing to comply with the requirements of the study
protocol

Exclusion Criteria:

1. Patients who have a history of any inflammatory disease which would be interfere with
outcome measurement

2. Patients who in the Investigator's opinion have a medical condition in which
participation in this trial is contraindicated

3. Patients who have received intramuscular, intravenous, or intraarticular (IM/IV/IA)
corticosteroids 28 days prior to baseline.

4. Patients who have active TB or a history of active TB (positive PPD skin test >5mm
and a positive chest x-Ray) or patients who have come in close contact with an
individual with active TB.

5. Patients with a history of acute or chronic viral hepatitis B or C or those who test
positive at screening.

6. Patients with a known human immunodeficiency virus (HIV) infection.

7. Concurrent malignancy or a history of malignancy other than a non-metastatic basal
cell or squamous cell cancer of the skin or cervical carcinoma in situ.

8. Patients who have a metal device affected by MRI (e.g. any type of electronic,
mechanical or magnetic implant; cardiac pacemaker; aneurysm clip(s); implanted
cardioverter defibrillator; or cochlear implant)

9. Patients who have potential ferromagnetic foreign body (metal slivers metal shavings,
other metal objects) for which they have sought medical attention

10. Patients at a high risk of infection in the Investigator's opinion or have had
recurrent infections requiring hospitalization or parenteral antimicrobial therapy
within the past 6 months.

11. Patients with an adverse reaction to tofacitinib

12. Patients with any other condition (e.g., clinically significant laboratory values)
which in the Investigator's judgment would make the patient unsuitable for inclusion
in this study

13. Patients who have received prohibited medications:

the following approved biological therapy for RA: etanercept, adalimumab, anakinra,
abatacept, tocilizumab within 28 days of baseline

- rituximab within 9 months of baseline

- infliximab within 56 days of baseline

- DMARDs other than methotrexate within 28 days of baseline

- any experimental biologic agent within three months or 5 half-lives prior to baseline

- exposure to JAK inhibitor 14. Female patients who are breast-feeding, pregnant, or
plan to become pregnant during the trial or within twelve weeks following last dose
of study drug