Carbon Monoxide-Saturated Medium for Islet Isolation



Status:Completed
Conditions:Gastrointestinal, Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 69
Updated:1/6/2019
Start Date:January 2015
End Date:December 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Novel Approach to Harvest Islets for Autologous Islet Transplantation

The goal of this study is to determine whether harvesting islets using carbon monoxide
(CO)-saturated mediums can protect islet cell from death after autologous islet
transplantation in patients with chronic pancreatitis.

Investigators plan to harvest human islets using carbon monoxide-saturated mediums. Survival
and function of transplanted islets will be compared with islets harvested using regular
mediums.

Inclusion Criteria:

1. Chronic pancreatitis patient selected for total pancreatectomy and islet
autotransplantation.

2. Age between 18-69.

Exclusion Criteria:

1. Had prior pancreatic surgeries.

Note: The study was initially designed only to enroll diabetes free patients. To increase
enrollment, we extended the inclusion criteria by allowing patients who are pre-diabetic to
participate the study. This revision was approved by the MUSC IRB on 11/10/2015.
We found this trial at
1
site
GI Surgery, Medical University of South Carolina
Charleston, South Carolina 29425
Phone: 843-876-4305
?
mi
from
Charleston, SC
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