Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma
Status: | Recruiting |
---|---|
Conditions: | Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | Any - 40 |
Updated: | 4/6/2019 |
Start Date: | May 23, 2016 |
A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS)
This randomized phase III trial studies how well combination chemotherapy (vincristine
sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan
hydrochloride or vinorelbine) works compared to combination chemotherapy plus temsirolimus in
treating patients with rhabdomyosarcoma (cancer that forms in the soft tissues, such as
muscle), and has an intermediate chance of coming back after treatment (intermediate risk).
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either
by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Combination chemotherapy and temsirolimus may stop the growth of tumor cells by blocking some
of the enzymes needed for cell growth. It is not yet known whether combination chemotherapy
or combination chemotherapy plus temsirolimus is more effective in treating patients with
intermediate-risk rhabdomyosarcoma.
sulfate, dactinomycin, cyclophosphamide alternated with vincristine sulfate and irinotecan
hydrochloride or vinorelbine) works compared to combination chemotherapy plus temsirolimus in
treating patients with rhabdomyosarcoma (cancer that forms in the soft tissues, such as
muscle), and has an intermediate chance of coming back after treatment (intermediate risk).
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either
by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Combination chemotherapy and temsirolimus may stop the growth of tumor cells by blocking some
of the enzymes needed for cell growth. It is not yet known whether combination chemotherapy
or combination chemotherapy plus temsirolimus is more effective in treating patients with
intermediate-risk rhabdomyosarcoma.
PRIMARY OBJECTIVES:
I. To compare the event-free survival (EFS) of patients with intermediate-risk (IR)
rhabdomyosarcoma (RMS) treated with surgery, radiotherapy, and vincristine (vincristine
sulfate), dactinomycin, and cyclophosphamide (VAC) alternating with vincristine and
irinotecan (irinotecan hydrochloride) (VI) (VAC/VI) with maintenance to that of patients
treated with surgery, radiotherapy and VAC/VI plus temsirolimus with maintenance.
SECONDARY OBJECTIVES:
I. To compare the overall survival (OS) of patients with IR RMS treated with surgery,
radiotherapy, and VAC alternating with VI with maintenance to that of patients treated with
surgery, radiotherapy and VAC/VI plus temsirolimus with maintenance.
EXPLORATORY OBJECTIVES:
I. To compare the outcome of patients based on their forkhead box O1 protein (FOXO1) fusion
gene partner, by evaluating paired box (PAX) 3 versus (vs) PAX7 in all patients found to be
FOXO1 fusion positive.
II. To compare the outcome of patients based on their [F18]-fluorodeoxy-D-glucose-positron
emission tomography (FDG-PET) response at week 9 (positive or negative), as assessed by
Deauville criteria (5-point).
III. To estimate the frequency of patients with circulating tumor deoxyribonucleic acid (DNA)
(ctDNA) at diagnosis and subsequent time-points.
IV. To compare the outcome of patients (VAC/VI with or without temsirolimus) who have
received maintenance therapy on ARST1431 to those who received VAC/VI on ARST0531.
OUTLINE:
FEASIBILITY PHASE (THE FEASIBILITY PHASE IS COMPLETE, EFFECTIVE WITH AMENDMENT #1A): (< 21
years old): This is a dose-escalation study of temsirolimus.
Patients receive vincristine sulfate intravenously (IV) over 1 minute on day 1 of weeks 1-13,
16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5 minutes on day 1
of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes on day 1 of weeks
1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes on days 1-5 of
weeks 4, 10, 16, 19, 25, 31, and 37, and temsirolimus IV over 30-60 minutes on days 1, 8, and
15. Patients also undergo radiation therapy (RT) beginning week 13 for up to 6.5 weeks.
Courses with temsirolimus repeat every 21 days for 12 weeks in the absence of disease
progression or unacceptable toxicity.
EFFICACY PHASE: Patients are randomized to Regimen A or B. Patients with disease that is ARMS
FOXO1 fusion negative (stage I, group I/II, stage 1, group III [orbit] or stage II, group
I/II) are assigned to Regimen C.
REGIMEN A (VAC/VI): Patients receive vincristine sulfate IV over 1 minute on day 1 of weeks
1-13, 16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5 minutes on
day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes on day 1 of
weeks 1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes on days 1-5
of weeks 4, 10, 16, 19, 25, 31, and 37. Patients also undergo primary site RT beginning at
week 13 or metastatic site RT beginning at week 43 for up to 6.5 weeks. Treatment continues
in the absence of disease progression or unacceptable toxicity. Patients then receive
vinorelbine IV over 6-10 minutes on days 1, 8, and 15 and cyclophosphamide orally (PO) once
daily (QD) on days 1-28. Cycles repeats every 28 days for 24 weeks in the absence of disease
progression or unacceptable toxicity.
REGIMEN B (VAC/VI TEMSIROLIMUS): Patients receive vincristine sulfate IV over 1 minute on day
1 of weeks 1-13, 16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5
minutes on day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes
on day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes
on days 1-5 of weeks 4, 10, 16, 19, 25, 31, and 37 and temsirolimus IV over 30-60 minutes on
day 1 of weeks 1-12 and 21-42. Patients also undergo RT as in Regimen A. Treatment continues
in the absence of disease progression or unacceptable toxicity. Patients then receive
vinorelbine IV over 6-10 minutes on days 1, 8, and 15 and cyclophosphamide PO QD on days
1-28. Cycles repeats every 28 days for 24 weeks in the absence of disease progression or
unacceptable toxicity.
MAINTENANCE PHASE (Patients in Regimen A or Regimen B): Patients receive vinorelbine IV over
6-10 minutes on days 1, 8, and 15 and cyclophosphamide orally (PO) once daily (QD) on days
1-28. Treatment repeats every 28 days for up to 6 cycles.
REGIMEN C (FOXO1 FUSION NEGATIVE): Patients receive vincristine sulfate IV over 1 minute on
day 1 of weeks 1-10 and 13-22, dactinomycin IV over 1-5 minutes on day 1 of weeks 1, 4, 7,
10, 13, 16, 19, and 22, cyclophosphamide IV over 60 minutes on day 1 of weeks 1, 4, 7, and
10. Patients undergo RT beginning at week 13 for up to 6.5 weeks. Treatment continues in the
absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 1 year,
every 4 months for 2 years, every 6 months for 1 year, and then annually for up to 10 years.
I. To compare the event-free survival (EFS) of patients with intermediate-risk (IR)
rhabdomyosarcoma (RMS) treated with surgery, radiotherapy, and vincristine (vincristine
sulfate), dactinomycin, and cyclophosphamide (VAC) alternating with vincristine and
irinotecan (irinotecan hydrochloride) (VI) (VAC/VI) with maintenance to that of patients
treated with surgery, radiotherapy and VAC/VI plus temsirolimus with maintenance.
SECONDARY OBJECTIVES:
I. To compare the overall survival (OS) of patients with IR RMS treated with surgery,
radiotherapy, and VAC alternating with VI with maintenance to that of patients treated with
surgery, radiotherapy and VAC/VI plus temsirolimus with maintenance.
EXPLORATORY OBJECTIVES:
I. To compare the outcome of patients based on their forkhead box O1 protein (FOXO1) fusion
gene partner, by evaluating paired box (PAX) 3 versus (vs) PAX7 in all patients found to be
FOXO1 fusion positive.
II. To compare the outcome of patients based on their [F18]-fluorodeoxy-D-glucose-positron
emission tomography (FDG-PET) response at week 9 (positive or negative), as assessed by
Deauville criteria (5-point).
III. To estimate the frequency of patients with circulating tumor deoxyribonucleic acid (DNA)
(ctDNA) at diagnosis and subsequent time-points.
IV. To compare the outcome of patients (VAC/VI with or without temsirolimus) who have
received maintenance therapy on ARST1431 to those who received VAC/VI on ARST0531.
OUTLINE:
FEASIBILITY PHASE (THE FEASIBILITY PHASE IS COMPLETE, EFFECTIVE WITH AMENDMENT #1A): (< 21
years old): This is a dose-escalation study of temsirolimus.
Patients receive vincristine sulfate intravenously (IV) over 1 minute on day 1 of weeks 1-13,
16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5 minutes on day 1
of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes on day 1 of weeks
1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes on days 1-5 of
weeks 4, 10, 16, 19, 25, 31, and 37, and temsirolimus IV over 30-60 minutes on days 1, 8, and
15. Patients also undergo radiation therapy (RT) beginning week 13 for up to 6.5 weeks.
Courses with temsirolimus repeat every 21 days for 12 weeks in the absence of disease
progression or unacceptable toxicity.
EFFICACY PHASE: Patients are randomized to Regimen A or B. Patients with disease that is ARMS
FOXO1 fusion negative (stage I, group I/II, stage 1, group III [orbit] or stage II, group
I/II) are assigned to Regimen C.
REGIMEN A (VAC/VI): Patients receive vincristine sulfate IV over 1 minute on day 1 of weeks
1-13, 16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5 minutes on
day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes on day 1 of
weeks 1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes on days 1-5
of weeks 4, 10, 16, 19, 25, 31, and 37. Patients also undergo primary site RT beginning at
week 13 or metastatic site RT beginning at week 43 for up to 6.5 weeks. Treatment continues
in the absence of disease progression or unacceptable toxicity. Patients then receive
vinorelbine IV over 6-10 minutes on days 1, 8, and 15 and cyclophosphamide orally (PO) once
daily (QD) on days 1-28. Cycles repeats every 28 days for 24 weeks in the absence of disease
progression or unacceptable toxicity.
REGIMEN B (VAC/VI TEMSIROLIMUS): Patients receive vincristine sulfate IV over 1 minute on day
1 of weeks 1-13, 16, 17, 19, 20, 22-26, 28, 31-34, 37, 38, and 40, dactinomycin IV over 1-5
minutes on day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, cyclophosphamide IV over 60 minutes
on day 1 of weeks 1, 7, 13, 22, 28, 34, and 40, irinotecan hydrochloride IV over 90 minutes
on days 1-5 of weeks 4, 10, 16, 19, 25, 31, and 37 and temsirolimus IV over 30-60 minutes on
day 1 of weeks 1-12 and 21-42. Patients also undergo RT as in Regimen A. Treatment continues
in the absence of disease progression or unacceptable toxicity. Patients then receive
vinorelbine IV over 6-10 minutes on days 1, 8, and 15 and cyclophosphamide PO QD on days
1-28. Cycles repeats every 28 days for 24 weeks in the absence of disease progression or
unacceptable toxicity.
MAINTENANCE PHASE (Patients in Regimen A or Regimen B): Patients receive vinorelbine IV over
6-10 minutes on days 1, 8, and 15 and cyclophosphamide orally (PO) once daily (QD) on days
1-28. Treatment repeats every 28 days for up to 6 cycles.
REGIMEN C (FOXO1 FUSION NEGATIVE): Patients receive vincristine sulfate IV over 1 minute on
day 1 of weeks 1-10 and 13-22, dactinomycin IV over 1-5 minutes on day 1 of weeks 1, 4, 7,
10, 13, 16, 19, and 22, cyclophosphamide IV over 60 minutes on day 1 of weeks 1, 4, 7, and
10. Patients undergo RT beginning at week 13 for up to 6.5 weeks. Treatment continues in the
absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 1 year,
every 4 months for 2 years, every 6 months for 1 year, and then annually for up to 10 years.
Inclusion Criteria:
- Feasibility Phase: Patients must be < 21 years of age at the time of enrollment;
please note: the feasibility phase is complete, effective with amendment #1
- Efficacy Phase: Patients must be =< 40 years of age at the time of enrollment
- Patients with newly diagnosed RMS of any subtype, except adult-type pleomorphic, based
upon institutional histopathologic classification, are eligible to enroll on the study
based upon stage, group, and age, as below
- RMS types included under embryonal rhabdomyosarcoma (ERMS) include those classified in
the 1995 International Classification of Rhabdomyosarcoma (ICR) as ERMS (classic,
spindle cell, and botryoid variants), which are reclassified in the 2013 World Health
Organization (WHO) classification as ERMS (classic, dense and botryoid variants) and
spindle cell/sclerosing RMS (encompassing the historical spindle cell ERMS variant and
the newly recognized sclerosing RMS variant); classification of alveolar
rhabdomyosarcoma (ARMS) in the 2013 WHO classification is the same as in the ICR and
includes classic and solid variants
- ERMS
- Stage 1, group III (non-orbit)
- Stage 3, group I/II
- Stage 2/3, group III
- Stage 4, group IV, < 10 years old
- ARMS:
- Stages 1-3, groups I-III
- Specimen Submission: Patients must have sufficient tissue available for the required
biology study
- Lansky performance status score >= 50 for patients =< 16 years of age; Karnofsky
performance status score >= 50 for patients > 16 years of age
- Peripheral absolute neutrophil count (ANC) >= 750/uL
- Platelet count >= 75,000/uL
- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:
- 1 month to < 6 months old: 0.4 mg/dl (male), 0.4 mg/dl (female)
- 6 months to < 1 year old: 0.5 mg/dl (male), 0.5 mg/dl (female)
- 1 to < 2 years old: 0.6 mg/dl (male), 0.6 mg/dl (female)
- 2 to < 6 years old: 0.8 mg/dl (male), 0.8 mg/dl (female)
- 6 to < 10 years old: 1 mg/dl (male), 1 mg/dl (female)
- 10 to < 13 years old: 1.2 mg/dl (male), 1.2 mg/dl (female)
- 13 to < 16 years old: 1.5 mg/dl (male), 1.4 mg/dl (female)
- >= 16 years old: 1.7 mg/dl (male), 1.4 mg/dl (female)
- Patients with an elevated serum creatinine due to obstructive hydronephrosis
secondary to tumor are still eligible; however, patients with urinary tract
obstruction by tumor must have unimpeded urinary flow established via diversion
(i.e. percutaneous nephrostomies or ureteric stents) of the urinary tract
- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age
- All patients and/or their parents or legal guardians must sign a written informed
consent.
- All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met.
Exclusion Criteria:
- Patients who have previously received temsirolimus, another mTOR inhibitor, or any
other investigational agent
- Patients who have received any chemotherapy (excluding steroids) and/or RT prior to
this enrollment
- Patients with uncontrolled hyperglycemia
- Patients with uncontrolled hyperlipidemia
- Sexually active patients of reproductive potential who have not agreed to use an
effective contraceptive method for the duration of their study participation and for
at least 3 months after treatment is completed
- Female patients who are pregnant are not eligible; Note: a pregnancy test is required
for female patients of childbearing potential prior to study entry
- Lactating females who plan to breastfeed their infants are not eligible
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Children's Hospital of The King's Daughters Children
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747 52nd St
Oakland, California 94609
Oakland, California 94609
(510) 428-3000
![Children's Hospital and Research Center Oakland](/wp-content/uploads/logos/children-s-hospital-and-research-center-oakland.jpg)
Principal Investigator: Carla B. Golden
Children's Hospital and Research Center Oakland For nearly 100 years, Children's Hospital & Research Center...
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1201 W La Veta Ave
Orange, California 92868
Orange, California 92868
(714) 997-3000
![Children's Hospital of Orange County](/wp-content/uploads/logos/children-s-hospital-of-orange-county.jpg)
Principal Investigator: Elyssa M. Rubin
Children's Hospital of Orange County For more than 45 years, CHOC Children’s has been steadfastly...
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5153 North 9th Avenue
Pensacola, Florida 32504
Pensacola, Florida 32504
(850) 505-4700
![Nemours Children's Clinic - Pensacola](/wp-content/uploads/logos/nemours-children-s-clinic---pensacola.jpg)
Principal Investigator: Scott M. Bradfield
Phone: 904-697-3529
Nemours Children's Clinic - Pensacola Nemours Children’s Clinic, Pensacola serves children and families in northwest...
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530 Northeast Glen Oak Avenue
Peoria, Illinois 61603
Peoria, Illinois 61603
(309) 624-4945
![Saint Jude Midwest Affiliate](/wp-content/uploads/logos/saint-jude-midwest-affiliate.png)
Principal Investigator: Jaime M. Libes
Phone: 888-226-4343
Saint Jude Midwest Affiliate The Jim and Trudy Maloof St. Jude Midwest Affiliate Clinic was...
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South 34th Street
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
215-590-1000
![Children's Hospital of Philadelphia](/wp-content/uploads/logos/children-s-hospital-of-philadelphia.gif)
Principal Investigator: Naomi J. Balamuth
Phone: 215-590-2810
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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4401 Penn Avenue
Pittsburgh, Pennsylvania 15224
Pittsburgh, Pennsylvania 15224
412-692-5325
![Children's Hospital of Pittsburgh of UPMC](/wp-content/uploads/logos/children-s-hospital-of-pittsburgh-of-upmc.jpg)
Principal Investigator: Scott H. Maurer
Phone: 412-692-5573
Children's Hospital of Pittsburgh of UPMC UPMC is one of the leading nonprofit health systems...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
![Providence Portland Medical Center](/wp-content/uploads/logos/providence-portland-medical-center.png)
Principal Investigator: Dan S. Zuckerman
Phone: 503-215-2614
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
![Oregon Health and Science University](/wp-content/uploads/logos/oregon-health-and-science-university.jpg)
Principal Investigator: Linda C. Stork
Phone: 503-494-1080
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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593 Eddy Street
Providence, Rhode Island 02903
Providence, Rhode Island 02903
401-444-4000
![Rhode Island Hospital](/wp-content/uploads/logos/rhode-island-hospital.png)
Principal Investigator: Jennifer J. Greene Welch
Phone: 401-444-1488
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
![University of Rochester](/wp-content/uploads/logos/university-of-rochester.png)
Principal Investigator: Angela R. Girvin
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
![University of Texas Health Science Center at San Antonio](/wp-content/uploads/logos/university-of-texas-health-science-center-at-san-antonio.jpg)
Principal Investigator: Anne-Marie R. Langevin
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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7700 Floyd Curl Dr
San Antonio, Texas 78229
San Antonio, Texas 78229
(210) 575-7000
![Methodist Children's Hospital of South Texas](/wp-content/uploads/logos/methodist-children-s-hospital-of-south-texas.png)
Principal Investigator: Vinod K. Gidvani-Diaz
Methodist Children's Hospital of South Texas Methodist Children
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3020 Childrens way
San Diego, California 92123
San Diego, California 92123
(858) 576-1700
![Rady Children's Hospital - San Diego](/wp-content/uploads/logos/rady-children-s-hospital---san-diego.jpg)
Principal Investigator: William D. Roberts
Phone: 858-966-5934
Rady Children's Hospital - San Diego Rady Children's Hospital-San Diego is the region’s pediatric medical...
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34800 Bob Wilson Dr,
San Diego, California 92134
San Diego, California 92134
(619) 532-6400
![Naval Medical Center - San Diego](/wp-content/uploads/logos/naval-medical-center---san-diego.png)
Principal Investigator: Yoko T. Udaka
Phone: 619-532-8712
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
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Seattle, Washington 98104
Principal Investigator: Dan S. Zuckerman
Phone: 206-215-3086
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1 Tampa General Cir
Tampa, Florida 33606
Tampa, Florida 33606
(813) 844-7000
![Tampa General Hospital](/wp-content/uploads/logos/tampa-general-hospital.png)
Principal Investigator: Juan F. Rico
Phone: 813-844-7829
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
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40 Sunshine Cottage Road
Valhalla, New York 10595
Valhalla, New York 10595
(914) 594-4000
![New York Medical College](/wp-content/uploads/logos/new-york-medical-college.jpg)
Principal Investigator: Jessica C. Hochberg
Phone: 914-594-3794
New York Medical College The College was founded in 1860 by a group of New...
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1600 Rockland Road
Wilmington, Delaware 19803
Wilmington, Delaware 19803
(302) 651-4200
![Alfred I. duPont Hospital for Children](/wp-content/uploads/logos/alfred-i-dupont-hospital-for-children.jpg)
Principal Investigator: Scott M. Bradfield
Phone: 302-651-6884
Alfred I. duPont Hospital for Children Nemours began more than 70 years ago with the...
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Aberdeen, Washington 98520
Principal Investigator: Dan S. Zuckerman
Phone: 360-412-8958
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Akron, Ohio 44308
Principal Investigator: Steven J. Kuerbitz
Phone: 330-543-3193
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Albany, New York 12208
Principal Investigator: Kenneth G. Lucas
Phone: 518-262-5513
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Allentown, Pennsylvania 18103
Principal Investigator: Felipe S. Bautista-Otanez
Phone: 734-712-3671
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Anaheim, California 92806
Principal Investigator: Robert M. Cooper
Phone: 800-398-3996
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 98508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 888-823-5923
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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Anchorage, Alaska 99504
Principal Investigator: Dan S. Zuckerman
Phone: 907-212-6871
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1540 East Hospital Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(877) 475-6688
![C S Mott Children's Hospital](/wp-content/uploads/logos/c-s-mott-children-s-hospital.jpg)
Principal Investigator: Rama Jasty
C S Mott Children's Hospital Behind the doors of C.S. Mott Children's Hospital there exist...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
![University of Michigan Comprehensive Cancer Center](/wp-content/uploads/logos/university-of-michigan-comprehensive-cancer-center.jpg)
Principal Investigator: Rama Jasty
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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921 North Oak Park Boulevard
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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Asheville, North Carolina 28801
Principal Investigator: Douglas J. Scothorn
Phone: 828-213-4150
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Atlanta, Georgia 30322
Principal Investigator: Kathryn S. Sutton
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Augusta, Georgia 30912
Principal Investigator: Colleen H. McDonough
Phone: 706-721-2388
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13123 E 16th Ave
Aurora, Colorado 80045
Aurora, Colorado 80045
(720) 777-1234
![Children's Hospital Colorado](/wp-content/uploads/logos/children-s-hospital-colorado.jpg)
Principal Investigator: Timothy P. Garrington
Children's Hospital Colorado At Children's Hospital Colorado, we see more, treat more and heal more...
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401 North Broadway
Baltimore, Maryland 21287
Baltimore, Maryland 21287
410-955-5000
![Johns Hopkins University-Sidney Kimmel Cancer Center](/wp-content/uploads/logos/johns-hopkins-university-sidney-kimmel-cancer-center.png)
Principal Investigator: Christine A. Pratilas
Phone: 410-955-8804
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
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22 South Greene Street
Baltimore, Maryland 21201
Baltimore, Maryland 21201
410-328-7904
![University of Maryland Greenebaum Cancer Center](/wp-content/uploads/logos/university-of-maryland-greenebaum-cancer-center.jpg)
Principal Investigator: Teresa A. York
Phone: 800-888-8823
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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489 State St
Bangor, Maine 04401
Bangor, Maine 04401
(207) 973-7000
![Eastern Maine Medical Center](/wp-content/uploads/logos/eastern-maine-medical-center.png)
Principal Investigator: Nadine P. SantaCruz
Phone: 207-973-4274
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
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265 Fremont St
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
(269) 245-8166
![Bronson Battle Creek](/wp-content/uploads/logos/bronson-battle-creek.png)
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
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Bellflower, California 90706
Principal Investigator: Robert M. Cooper
Phone: 800-398-3996
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Bellingham, Washington 98225
Principal Investigator: Dan S. Zuckerman
Phone: 360-715-4133
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Bend, Oregon 97701
Principal Investigator: Dan S. Zuckerman
Phone: 541-706-2909
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Berlin, Vermont 05602
Principal Investigator: Jessica L. Heath
Phone: 802-225-5400
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100 E Idaho St
Boise, Idaho 83712
Boise, Idaho 83712
(208) 381-2711
![Saint Luke's Mountain States Tumor Institute](/wp-content/uploads/logos/saint-luke-s-mountain-states-tumor-institute.gif)
Principal Investigator: Eugenia Chang
Saint Luke's Mountain States Tumor Institute For more than 100 years, St. Luke
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55 Fruit St
Boston, Massachusetts 02114
Boston, Massachusetts 02114
(617) 724-4000
![Massachusetts General Hospital Cancer Center](/wp-content/uploads/logos/massachusetts-general-hospital-cancer-center.jpg)
Principal Investigator: Katherine A. Janeway
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center An integral part of one of the world
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450 Brookline Ave
Boston, Massachusetts 2215
Boston, Massachusetts 2215
617-632-3000
![Dana-Farber Cancer Institute](/wp-content/uploads/logos/dana-farber-cancer-institute.gif)
Principal Investigator: Katherine A. Janeway
Phone: 877-442-3324
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, Massachusetts 02111
Principal Investigator: Michael J. Kelly
Phone: 617-636-5535
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Bridgeport, West Virginia 26330
Principal Investigator: Stephan R. Paul
Phone: 304-293-7374
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Bronx, New York 10461
Principal Investigator: Lisa Gennarini
Phone: 718-379-6866
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Bronx, New York 10461
Principal Investigator: Lisa Gennarini
Phone: 718-379-6866
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Bronx, New York 10467
Principal Investigator: Lisa Gennarini
Phone: 888-823-5923
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Bronx, New York 10467
Principal Investigator: Lisa Gennarini
Phone: 718-379-6866
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Burbank, California
Principal Investigator: Dan S. Zuckerman
Phone: 818-847-4793
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Burlington, Vermont 05405
Principal Investigator: Jessica L. Heath
Phone: 802-656-4101
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Carson City, Nevada 89703
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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Centralia, Washington 98531
Principal Investigator: Dan S. Zuckerman
Phone: 360-412-8958
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Chapel Hill, North Carolina 27599
Principal Investigator: Stuart H. Gold
Phone: 877-668-0683
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
![Medical University of South Carolina](/wp-content/uploads/logos/medical-university-of-south-carolina.jpg)
Principal Investigator: Jacqueline M. Kraveka
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charlotte, North Carolina 28204
Principal Investigator: Joel A. Kaplan
Phone: 800-804-9376
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Charlotte, North Carolina 28204
Principal Investigator: Jessica A. Bell
Phone: 704-384-5369
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Charlotte, North Carolina 28207
Principal Investigator: Jessica A. Bell
Phone: 704-384-8920
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Charlotte, North Carolina 28207
Principal Investigator: Jessica A. Bell
Phone: 704-384-8920
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Charlotte, North Carolina 28262
Principal Investigator: Jessica A. Bell
Phone: 704-384-8920
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Chattanooga, Tennessee 37403
Principal Investigator: Manoo G. Bhakta
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5841 S Maryland Ave
Chicago, Illinois 60637
Chicago, Illinois 60637
1-773-702-6180
![University of Chicago Comprehensive Cancer Center](/wp-content/uploads/logos/university-of-chicago-comprehensive-cancer-center.png)
Principal Investigator: Susan L. Cohn
Phone: 773-702-8222
University of Chicago Comprehensive Cancer Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
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Chicago, Illinois 60614
Principal Investigator: David O. Walterhouse
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1969 W Ogden Ave
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 864-6000
![John H. Stroger, Jr. Hospital of Cook County](/wp-content/uploads/logos/john-h-stroger-jr-hospital-of-cook-county.png)
Principal Investigator: Mary L. Schmidt
Phone: 312-864-5204
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
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1653 W. Congress Parkway
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 942-5000
![Rush University Medical Center](/wp-content/uploads/logos/rush-university-medical-center.jpg)
Principal Investigator: Mary L. Schmidt
Phone: 312-942-5498
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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1200 West Harrison Stree
Chicago, Illinois 60607
Chicago, Illinois 60607
(312) 996-4350
![Univ of Illinois](/wp-content/uploads/logos/univ-of-illinois.jpg)
Principal Investigator: Mary L. Schmidt
Phone: 312-355-3046
Univ of Illinois A major research university in the heart of one of the world's...
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Clackamas, Oregon 97015
Principal Investigator: Dan S. Zuckerman
Phone: 503-215-2614
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9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
Clackamas, Oregon 97015
(503) 513-3300
![Clackamas Radiation Oncology Center](/wp-content/uploads/logos/clackamas-radiation-oncology-center.jpg)
Principal Investigator: Dan S. Zuckerman
Phone: 503-215-2614
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
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2049 E 100th St
Cleveland, Ohio 44106
Cleveland, Ohio 44106
(216) 444-2200
![Cleveland Clinic Foundation](/wp-content/uploads/logos/cleveland-clinic-foundation.jpg)
Principal Investigator: Rabi Hanna
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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5 Richland Medical Park Dr
Columbia, South Carolina 29203
Columbia, South Carolina 29203
(803) 434-7000
![Palmetto Health Richland](/wp-content/uploads/logos/palmetto-health-richland.png)
Principal Investigator: Stuart L. Cramer
Phone: 803-434-3680
Palmetto Health Richland Palmetto Health Richland, originally founded in 1892 as Columbia Hospital, has a...
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