A Comparison of Magnetic Resonance Imaging in Persons With Heart Failure to Health, Aged Matched Controls

The purpose of this study is use neuroimaging techniques to better understand the underlying
structural brain changes and physiological mechanisms that guide the thinking and decision
making processes required for people with heart failure. The study will compare how the
underlying brain structures and circulation are similar to or different in persons with heart
failure to healthy, aged matched controls using special neuroimaging procedures.

Inclusion Criteria:

Participants with heart failure:

- Speak and understand English

- Live independently within a 60 mile radius of Atlanta

- Montreal Cognitive Assessment (MOCA) score of less than or equal to 24

- Documented medical diagnosis of New York Heart Association (NYHA) class II or III
systolic

- Left ventricular ejection fraction (LVEF) greater than or equal to 10% that is
documented within the last year by echocardiogram, cardiac catheterization
ventriculography, or radionuclide ventriculography

- Receiving medication therapy for heart failure (HF) according to American College of
Cardiology (ACC) American Heart recommendation guidelines for at least 8 weeks prior
to study enrollment

Healthy Controls

- Speak and understand English

- Live independently within a 60 mile radius of Atlanta

Exclusion Criteria:

Participants with heart failure:

- New York Heart Association (NYHA) class I or IV

- Change in heart failure (HF) therapy within 6 months

- Worsening of heart failure (HF) symptoms within last 5 days

- Unstable angina

- Renal insufficiency (serum creatinine greater than 3.o mg/dL)

- Hospitalized within the last 30-days

- Diagnosed with any neurological disorder that may interfere with cognitive function

- Beck Depression Inventory II (BDI-II) score greater than 25

- Claustrophobia

- Implanted devices such as internal cardiac defibrillator or pacemaker

- Carrying non-removable objects

- Stents

- Body weight more than 120 kg

Healthy Controls

- Taking prescription medications

- Cardiovascular disease;

- Cerebrovascular disease

- Neurological disease

- Respiratory disease

- Claustrophobia

- Any implanted metal objects not considered safe or appropriate for the MRI
environment.