GR-MD-02 Plus Pembrolizumab in Melanoma, Non-small Cell Lung Cancer, and Squamous Cell Head and Neck Cancer Patients

This study will employ a 3+3 phase I design with dose escalation of GR-MD-02 in conjunction
with the standard therapeutic dose of pembrolizumab in patients with advanced melanoma who
have had progression after ipilimumab and/or BRAF targeted therapy when a BRAF mutation is
present, non-small cell lung cancer patients with disease progression after targeted therapy,
or head and neck squamous cell carcinoma patients with disease progression after at least one
platinum-containing regimen.

In addition to monitoring for toxicity and clinical response, blood and tumor samples will be
obtained to assess immunologic measures relevant to galectin biology and pembrolizumab T-cell
checkpoint inhibition.

Inclusion Criteria:

- Patients with metastatic or unresectable melanoma for whom treatment with
pembrolizumab is indicated. Histological confirmation of melanoma will be required by
previous biopsy or cytology.

- Patients with non-small cell lung cancer for whom treatment with pembrolizumab is
indicated.

- Patients with squamous cell carcinoma of the head and neck for whom treatment with
pembrolizumab is indicated

- Patients who have radiographic progression using Response Evaluation Criteria In Solid
Tumors (RECIST) currently on pembrolizumab are also eligible.

- Patients must be ≥ 18 years of age.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

- Women of childbearing potential must have a serum or urine pregnancy test performed
within 72 hours prior to the start of protocol treatment. The results of this test
must be negative in order for the patient to be eligible. In addition, women of
childbearing potential as well as male patients must agree to take appropriate
precautions to avoid pregnancy.

- No active bleeding.

- Anticipated lifespan greater than 12 weeks.

- Patients must sign a study-specific consent document.

Exclusion Criteria:

- Patients who have previously received a galectin antagonist

- Patients with active autoimmune disease except for autoimmune thyroiditis or vitiligo

- Patients with history of colitis

- Patients with untreated brain metastases. Patients with treated brain metastases who
demonstrate control of brain metastases with follow-up imaging 4 or more weeks after
initial therapy are eligible.

- Other active metastatic cancer requiring treatment.

- Patients with active infection requiring antibiotics.

- Pregnant or lactating women, as treatment involves unforeseeable risks to the embryo
or fetus.

- Need for chronic steroids. Inhaled corticosteroids are acceptable.

- Laboratory values (to be performed within 28 days of enrollment) outside of
protocol-specified ranges.

- Inability to give informed consent and comply with the protocol. Patients with a
history of psychiatric illness must be judged able to understand fully the
investigational nature of the study and the risks associated with the therapy.

- Any medical condition that in the opinion of the Principal Investigator would
compromise the safety or conduct of the study procedures.

- Unresolved immune-mediated pneumonitis, diarrhea, elevation of hepatocellular enzymes
or other toxicities requiring greater than physiological replacement doses of
steroids.