Food Effect Study of AG120 in Healthy Subjects

Inclusion Criteria:

1. males or females, aged 18 to 55 years, inclusive

2. within body mass index (BMI) range of 18 to 33 kg/m2, inclusive

3. in good health, determined by absence of clinically significant findings from medical
history, 12-lead ECG, and vital signs

4. fasted clinical laboratory values within the normal reference range for the test
laboratory, unless deemed not clinically significant by the Investigator. (Calcium,
magnesium, and potassium levels within normal ranges)

5. negative test for selected drugs of abuse and cotinine at Screening (does not include
alcohol) and at Check-in of Period 1 (Parts 1 and 2) and Period 2 (Part 1) (does
include alcohol via breathalyzer)

6. negative hepatitis panel (including hepatitis B surface antigen and hepatitis C virus
antibody) and negative human immunodeficiency virus (HIV) antibody screens

7. female subjects with reproductive potential must agree to undergo medically
supervised pregnancy test prior to study drug administration. Pregnancy tests will be
performed at Screening and confirmed negative at each Check-in

8. females of reproductive potential must agree to abstain from sexual intercourse or to
use 2 highly effective forms of contraception from the time of giving informed
consent, during the study, and for 90 days following the last dose of AG-120.

9. males must either be sterile or agree to use 2 of the following approved methods of
contraception from time of giving informed consent until 90 days following the last
dose administration. Subjects will refrain from sperm donation from time of giving
informed consent until 90 days following the last dose administration

10. able to comprehend and willing to sign an Informed Consent Form (ICF)

Exclusion Criteria:

1. history or clinical manifestation of any metabolic, allergic, dermatological,
hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal,
neurological, or psychiatric disorder (as determined by the Investigator)

2. history of significant hypersensitivity, intolerance, or allergy to any drug
compound, food, or other substance, unless approved by the Investigator

3. history of stomach or intestinal surgery or resection that would potentially alter
absorption and/or excretion of orally administered drugs except that appendectomy and
hernia repair will be allowed

4. history or presence of an abnormal ECG, which, in the Investigator's opinion, is
clinically significant. QTcF values must be within ranges indicated in inclusion
criteria #3

5. history of alcoholism or drug addiction within 2 years before first dose
administration, or positive drug screening test reflecting consumption of illicit
drugs or positive alcohol screen at each Check-in

6. use of any tobacco- or nicotine-containing products (including but not limited to
cigarettes, e-cigarettes, pipes, cigars, chewing tobacco, nicotine patches, nicotine
lozenges, or nicotine gum) within 6 months prior to Screening through Study
Completion, or positive cotinine screen at Screening or each Check-in

7. unwilling to refrain from strenuous exercise from 48 hours prior to each Check-in and
during the period of confinement at the Clinical Research Unit and otherwise maintain
their normal level of physical activity throughout the entire study (ie, will not
begin a new exercise program nor participate in any unusually strenuous physical
exertion)

8. participation in any other clinical trial in which an investigational study drug was
administered within 5 half-lives or 30 days from Screening, whichever is longer

9. use of hormonal oral, implantable, injectable, or transdermal contraceptives from the
time of signing the ICF (females only) until 90 days after the last dose
administration

10. use of any prescription medications/products within 14 days prior to initial Check-in
through Study Completion, unless deemed acceptable by the Investigator

11. use of any over-the-counter, nonprescription preparations including vitamins,
minerals, and phytotherapeutic/herbal/plant-derived preparations, within 7 days prior
to initial Check-in through Study Completion, unless deemed acceptable by the
Investigator

12. poor peripheral venous access

13. donation of blood or plasma within 8 weeks before first dose administration through
Study Completion

14. receipt of blood products within 2 months prior to initial Check-in and for at least
28 days following the last dose of study drug

15. any acute or chronic condition that, in the opinion of the Investigator, would limit
the subject's ability to complete and/or participate in this clinical study