Cognitive Rehabilitation and Brain Activity of Attention Control in TBI

Attention impairment is ubiquitous in TBI survivors. This is a devastating impairment because
attention is the backbone of cognitive systems. Attention is requisite for other cognitive
processes that are vital to everyday functioning such as memory, problem solving, language
skills, and the cognitive control of behavior. Studies of attention training have shown
improved attention on laboratory measures, but limited translation to real-world tasks.
Notably, these previously-tested rehabilitation approaches have not included training in the
very cognitive processes needed for translation of training to everyday tasks which include
internal verbalization and self-monitoring, also called metacognitive strategies. One
training method for metacognitive strategies has shown promise, but is lacking in basic
attention training. Rehabilitation specialists have recently argued for a rehabilitation
approach wherein both basic foundational attention and metacognitive strategies should be
synergistically combined. Consequently, the investigators will test an innovative combination
of direct-attention training and metacognitive training for which the other compensates
disadvantages of each. Because of the promise of each type of training separately, and the
potential additive effects of the combination, it is critical to test this combined attention
and metacognitive training in Veteran survivors of chronic moderate-to-severe traumatic brain
injury (TBI). The investigators will address the following two specific aims: the
investigators propose to conduct a pilot study to examine cognitive rehabilitation therapy
(CRT) effects in a group of Veterans with chronic moderate to severe TBI (m/sTBI), focused on
remediating attention-control impairments using both direct-attention and
metacognitive-strategy training approaches in a AB/BA crossover design with 1-month follow-up
to address the following two specific aims: 1) Test treatment response to combined
direct-attention and metacognitive-strategy training in Veterans with chronic m/sTBI; and 2)
identify mechanisms and biomarkers of rehabilitation-related neuroplasticity. Under the first
aim the investigators will test for effects of combined direct-attention and
metacognitive-strategy training on measures of complex functional activities and
neurocognitive tests of attention-control functions. Under the second aim, the investigators
will test effects of the their CRT approach on behavioral and brain activity while
participants perform a well-validated attentional task that probes the function of three
dissociable attentional systems. The approach is innovative because it combines a
theoretically motivated and novel approach to address a significant source of disability in
Veteran survivors of TBI. The proposed research is significant because findings will form the
foundation for a larger-scale trial to enable us to determine the durability of gains and the
functional impact of treatment on Veteran's real world activities and to more positively
shape healthcare for our Veterans who are suffering from TBI. Outcome measures will include
standardized tests of neurocognitive functioning such as attention and other cognitive
skills, measures of self care, ability to live independently, social role participation, life
satisfaction, TBI-related quality of life, mood/anxiety, and attention-related scalp-recorded
brain event-related potentials (ERPs, derived from electroencephalography).

Inclusion Criteria:

- OEF/OIF/OND Veterans with moderate or severe TBI as described by DOD/VA common
definition.

- Self-report of attentional problems, confirmed with psychometric testing.

- Ruff 2 & 7 selective attention task score <= 1.5 standard deviations from
demographically-matched norms.

- Able to participate in study at 12-60 months post injury without contraindications.

- Age 21-55 years.

- Willingness to be randomized and to participate in treatment procedures.

- Capacity to visit the laboratory for repeated treatment and testing sessions.

- Access to internet-enabled home computer.

- English as Native language.

- Adequate reading comprehension to allow completion of study-related questionnaires.

- Reliable digit span (RDS) score > 7.

Exclusion Criteria:

- Pre-existing neurological disorder associated with cerebral dysfunction (e.g., stroke,
history of epilepsy or chronic seizure disorder).

- Current alcohol or drug use/dependence.

- Pre-existing severe psychiatric disorder (e.g., schizophrenia, bipolar disorder) or
history of psychiatric diagnosis sufficiently severe to have resulted in inpatient
hospitalization.

- Current suicidal or homicidal ideation.

- Reported involvement in current litigation.

- Reported history of pre-injury learning disability.

- Not competent to provide written informed consent (i.e., not able to demonstrate
understanding or expectations of study and potential risks of participation).

- Does not fully understand the nature of the study and requirements of participation.

- Does not understand task instructions.

- Validity testing score on RDS <= 7.