Compassionate Use Arm - ABI541 ABI for 10 NF2 Patients

Currently, the Nucleus 24 (ABI24M) Auditory Brainstem Implant (ABI) is approved for use in
individuals 12 years of age or older who have been diagnosed with Neurofibromatosis Type 2
(NF2). Implantation may occur during first or second side tumor removal or in patients with
previously removed vestibular schwannomas bilaterally. As the ABI24M is now obsolete, there
is currently no commercially approved device available to restore useful hearing in
patients. While the manufacturer of the device is pursuing commercial approval of the
ABI541, it is anticipated that it may be several months or years before final approval.
However, it is preferable to place the device at the time of tumor removal while the patient
has an open craniotomy site, thereby avoiding a second surgery and its associated risks
solely for the purpose device implantation. In addition, placement of an ABI at the time of
tumor removal optimizes auditory rehabilitation, providing critical auditory sensations that
may more effectively maintain auditory pathways. The FDA approved a compassionate use arm
for an ongoing clinical trial to permit implantation of the ABI541 in up to 10 NF2 patients.

Patients will undergo pre-operative evaluation for ABI surgery. Those who are appropriate
for surgery will undergo a procedure for implantation of the ABI541. As per manufacturer
protocol, the parameters of the ABI541 including adjustment of electrode sensitivities and
activation of specific electrodes will be completed at each follow-up visit
post-operatively. This process involves adjustment of device parameters by a trained
audiologist who subsequently administers audiologic tests to confirm optimal activation of
the ABI541.

All audiologic testing and assessments represent the standard of care. These post-operative
follow-up appointments will occur at 4-12 weeks, three, six, and twelve months, and
biannually thereafter. Timing of these appointments may vary by as much as four weeks prior
to or after the planned follow-up date (e.g. between 2-4 months for the 3 month follow-up).
Unscheduled visits will be taken in the Otology clinic as needed to address any concerns
patients may have regarding the use of their Nucleus ABI541.

Inclusion Criteria:

- Diagnosis of Neurofibromatosis Type 2;

- Age of 12 years or older

- Will be anticipated to be completely deaf as a result of bilateral neurofibromas of
the auditory nerve, and/or their surgical removal.

Exclusion Criteria:

- Contraindications to surgery or general anesthesia

- Intractable seizures or progressive, deteriorating neurological disorder

- Unable to participate in behavioral testing and mapping with ABI

- Unrealistic expectations on the part of the subject/family regarding possible
benefits, risks, and limitations that are inherent to the procedure and prosthetic
device