Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads

Inclusion Criteria:

- Standard CRT-D indication according to clinical routine

- De novo implantation or upgrade from existing ICD or pacemaker implant utilizing a
BIOTRONIK CRT-D system with IS4 LV port and Sentus QP LV lead

- Patient is able to understand the nature of the clinical investigation and provide
written informed consent

- Patient is able and willing to complete all routine study visits at the
investigational site through 5 years of follow-up

- Patient accepts Home Monitoring® concept

- Age ≥ 18 years

Exclusion Criteria:

- Contraindication to CRT-D therapy

- Currently implanted with an endocardial or epicardial left ventricular lead or had
prior attempt to place a left ventricular lead

- Cardiac surgical procedure, such as coronary artery bypass graft or valve surgery that
is planned to occur within 6 months after implant or ablation that is planned to occur
within 90 days after implant (ablations planned to occur prior to or at implant are
not exclusionary)

- Expected to receive a heart transplant or ventricular assist device within 6 months

- Life expectancy less than 12 months

- Participation in any other investigational cardiac clinical investigation during the
course of the study

- Presence of another life-threatening, underlying illness separate from their cardiac
disorder

- Pregnant or breast-feeding at time of enrollment