PF-06372865 in Subjects With Photosensitive Epilepsy



Status:Completed
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 60
Updated:4/17/2018
Start Date:December 16, 2015
End Date:February 7, 2017

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A Double Blind, Randomized, Cross- Over Study Examining Efficacy Of Pf-06372865 In A Photosensitivity Epilepsy Study Using Lorazepam As A Positive Control

PF-06372865 in subjects with photosensitive epilepsy


Inclusion Criteria:

- A diagnosis and history of photoparoxysmal response on electroencephalogram (EEG) with
or without a diagnosis of epilepsy for which subjects are taking up to 0 - 2
concomitant antiepileptic drugs.

- Subjects currently taking antiepileptic drug(s) to be on a stable dose for 4 weeks
prior to Screening Visit.

- A minimum average standardized photosensitive range (SPR) across all screening
timepoints of 4 in the most sensitive eye condition and a non-zero average in at least
one other eye condition.

Exclusion Criteria:

- Subjects with a history of status epilepticus.

- Subjects who have experienced a generalized tonic-clonic convulsion in the past 6
months, at the time of the initial screening visit.
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