A Phase I Dose Escalation Study of the Safety and Pharmacokinetics of LAM-002A In Patients With Non-Hodgkin's Lymphoma (LAM-002A/NHL)

LAM-002A is supplied as 25-mg or 50-mg capsules and will be administered two times daily or
three times daily by mouth in repeated 28-day cycles. Patients will be advised to take the
doses at the same time each day.

A 3 + 3 design will be utilized to define a maximum tolerated dose (MTD). The MTD is defined
as the highest dose at which no more than 1 of 6 patients (i.e., < 33%) experiences a
dose-limiting toxicity (DLT) in the dose cohort.

Once the dose and schedule are established, additional patients will be treated to better
characterize the safety, tolerability,PK, PD, and anti-tumor activity of LAM-002A when
administered alone or in combination with rituximab or atezolizumab.

Inclusion Criteria:

1. Able to understand and comply with the protocol requirements and has signed the
informed consent document.

2. Confirmed diagnosis of B-cell Non-Hodgkin's lymphoma limited to follicular lymphoma
(FL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), marginal zone
lymphoma (MZL), primary mediastinal B-cell lymphoma (PMBL), or chronic lymphocytic
leukemia/small lymphocytic lymphoma (CLL/SLL) that has progressed and for which
standard curative measures do not exist or are no longer effective. Prior therapy must
have included a rituximab-based regimen.

3. Patients with DLBCL: Cancer progression after transplant, or be unwilling, unable or
not an appropriate candidate for an autologous stem cell or bone marrow transplant

4. Radiographically measurable lymphadenopathy or extranodal lymphoid malignancy (defined
as the presence of 1 or more lesions that measure at least 2.0 cm in the longest
dimension (as assessed radiographically)

5. Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or less.

6. Adequate organ and marrow function.

7. Able to swallow oral capsules without difficulty.

8. Acceptable birth control.

9. Women of childbearing potential : negative pregnancy test

10. Adequate archival or fresh tumor tissue (from biopsy, bone marrow, or peripheral
blood) for analysis of potential predictive biomarkers.

Exclusion Criteria:

1. Patients with central nervous system (CNS) lymphoma are not eligible for the trial
unless the disease had been treated and the subject remains without symptoms with no
active CNS lymphoma.

2. Not recovered from toxicity due to all prior therapies.

3. Other uncontrolled significant illness.

4. History of malabsorption or other gastrointestinal (GI) disease that may significantly
alter the absorption of LAM-002A

5. Major surgery within 28 days prior to first dose of study drug.

6. Past history of tuberculosis (TB) or active infection with TB, human immunodeficiency
virus (HIV), hepatitis B or hepatitis C.

7. Lactation or breast feeding.

8. Unable or unwilling to abide by the study protocol or cooperate fully with the
Investigator or designee.

This is a shortened list and additional criteria may apply.