Cisplatin, Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery
Status: | Recruiting |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 1/3/2019 |
Start Date: | November 6, 2015 |
End Date: | January 1, 2029 |
Randomized Phase II Study of Cisplatin and Etoposide Versus Temozolomide and Capecitabine in Patients With Advanced G3 Non-small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
This randomized phase II trial studies how well temozolomide and capecitabine work compared
to standard treatment with cisplatin or carboplatin and etoposide in treating patients with
neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other
parts of the body (metastatic) or cannot be removed by surgery. Drugs used in chemotherapy,
such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different
ways to stop the growth of tumor cells, either by killing the cells, by stopping them from
dividing, or by stopping them from spreading. Certain types of neuroendocrine carcinomas may
respond better to treatments other than the current standard treatment of cisplatin and
etoposide. It is not yet known whether temozolomide and capecitabine may work better than
cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine
carcinoma, called non-small cell neuroendocrine carcinoma.
to standard treatment with cisplatin or carboplatin and etoposide in treating patients with
neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other
parts of the body (metastatic) or cannot be removed by surgery. Drugs used in chemotherapy,
such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different
ways to stop the growth of tumor cells, either by killing the cells, by stopping them from
dividing, or by stopping them from spreading. Certain types of neuroendocrine carcinomas may
respond better to treatments other than the current standard treatment of cisplatin and
etoposide. It is not yet known whether temozolomide and capecitabine may work better than
cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine
carcinoma, called non-small cell neuroendocrine carcinoma.
PRIMARY OBJECTIVES:
I. To assess the progression free survival (PFS) of platinum (cisplatin or carboplatin) and
etoposide versus the PFS of temozolomide and capecitabine in patients with advanced G3
non-small cell gastroenteropancreatic neuroendocrine carcinomas.
SECONDARY OBJECTIVES:
I. To assess the response rate (RR) of platinum (cisplatin or carboplatin) and etoposide
versus the RR of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.
II. To assess the overall survival (OS) of platinum (cisplatin or carboplatin) and etoposide
versus the OS of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.
III. To evaluate the toxicities associated with the combination of temozolomide and
capecitabine and the combination of platinum (cisplatin or carboplatin) and etoposide,
respectively, in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas.
TERTIARY OBJECTIVES:
I. To assess the impact of each treatment regimen on PFS, RR and OS based on marker of
proliferation Ki-67 index in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas. (Laboratory) II. To assess the prognostic significance of well
differentiated versus poorly differentiated non-small cell gastroenteropancreatic
neuroendocrine tumors in relationship to survival and response to treatment. (Laboratory)
III. To assess the agreement in Ki-67 status between that reported by institutional
pathologist and that reported by central pathology review. (Laboratory)
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and
temozolomide PO once daily (QD) on days 10-14. Courses repeat every 28 days in the absence of
disease progression or unacceptable toxicity.
ARM B: Patients receive cisplatin intravenously (IV) on days 1-3 or carboplatin IV on day 1.
Patients also receive etoposide IV on days 1-3. Courses repeat every 21 days in the absence
of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.
I. To assess the progression free survival (PFS) of platinum (cisplatin or carboplatin) and
etoposide versus the PFS of temozolomide and capecitabine in patients with advanced G3
non-small cell gastroenteropancreatic neuroendocrine carcinomas.
SECONDARY OBJECTIVES:
I. To assess the response rate (RR) of platinum (cisplatin or carboplatin) and etoposide
versus the RR of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.
II. To assess the overall survival (OS) of platinum (cisplatin or carboplatin) and etoposide
versus the OS of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.
III. To evaluate the toxicities associated with the combination of temozolomide and
capecitabine and the combination of platinum (cisplatin or carboplatin) and etoposide,
respectively, in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas.
TERTIARY OBJECTIVES:
I. To assess the impact of each treatment regimen on PFS, RR and OS based on marker of
proliferation Ki-67 index in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas. (Laboratory) II. To assess the prognostic significance of well
differentiated versus poorly differentiated non-small cell gastroenteropancreatic
neuroendocrine tumors in relationship to survival and response to treatment. (Laboratory)
III. To assess the agreement in Ki-67 status between that reported by institutional
pathologist and that reported by central pathology review. (Laboratory)
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and
temozolomide PO once daily (QD) on days 10-14. Courses repeat every 28 days in the absence of
disease progression or unacceptable toxicity.
ARM B: Patients receive cisplatin intravenously (IV) on days 1-3 or carboplatin IV on day 1.
Patients also receive etoposide IV on days 1-3. Courses repeat every 21 days in the absence
of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.
Inclusion Criteria:
- Patients must have a locally advanced and unresectable or metastatic
gastroenteropancreatic neuroendocrine carcinoma that is either known or suspected to
be of gastrointestinal (GI) origin; primary tumors arising from the lung, gynecologic
organs or prostate are not permitted
- Patients must have pathologically/histologically confirmed tumor of non-small cell
histology
- Patients must have a Ki-67 proliferative index of 20-100% OR at least 10 mitotic
figures per 10 high powered fields
- Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors
(RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease
must be obtained within 4 weeks prior to randomization and must be acquired by
multiphasic computed tomography (CT) or contrast magnetic resonance imaging (MRI)
- NOTE: positron emission tomography (PET)-CT scans are allowed provided the CT
portion of the exam is equivalent to a diagnostic CT scan and includes both oral
and IV contrast
- Patients may not have had any prior systemic treatment for this malignancy (for
example chemotherapy or somatostatin analogues); prior palliative radiation is
permitted but radiated lesions may not be used for measurement
- Patients may not have received any of the protocol agents within 5 years prior to
randomization
- Any prior surgeries must have been completed at least 4 weeks prior to randomization
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0-2
- Patients may not be receiving any other investigational agents while on study
treatment
- Patients may not be receiving Coumadin while on treatment; other anticoagulants are
allowed
- Leukocytes >= 3,000/mm^3
- Absolute neutrophil count >= 1,500/mm^3
- Hemoglobin >= 9 g/dL
- Platelets >= 100,000/mm^3
- Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional
ULN (if the patient has liver metastases)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
=< 2.5 X institutional ULN or (=< 5 X institutional ULN if the patient has liver
metastases)
- Serum creatinine =< 1.5 X institutional ULN and creatinine clearance >= 60 ml/min
- NOTE: creatinine clearance must be calculated using the Cockcroft-Gault equation
- Patients must have a life expectancy of >= 12 weeks as determined clinically by the
treating physician
- Patients with brain metastases (either remote or current) or presence of carcinomatous
meningitis are not eligible
- Patients with known dihydropyrimidine dehydrogenase (DPD) deficiency will be excluded
- Patients must NOT have active or uncontrolled infection, symptomatic heart failure,
unstable angina pectoris, cardiac arrhythmia or a serious psychiatric illness/social
situation that would limit compliance with study requirements
- Patients with impaired decision making capacity may participate in the study if a
legal authorized representative is available to consent
- Patients must NOT have a history of allergic reactions attributed to compounds of
similar chemical or biochemical composition to cisplatin, carboplatin, etoposide,
temozolomide or capecitabine
- Patients must NOT have absorption issues that would limit the ability to absorb study
agents
- Patients with a history of the following within =< 12 months of study entry are not
eligible:
- Arterial thromboembolic events
- Unstable angina
- Myocardial Infarction
- Patients with symptomatic peripheral vascular disease are not eligible
- Patients must NOT have previous or concurrent malignancy; exceptions are made for
patients who meet any of the following conditions:
- Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or
breast cancer in situ OR
- Prior malignancy completely excised or removed and patient has been continuously
disease free for > 5 years OR
- Prior malignancy cured by non-surgical modalities and patient has been
continuously disease free for > 5 years
- Women must not be pregnant or breast-feeding
- All females of childbearing potential must have a blood test or urine study
within 2 weeks prior to randomization to rule out pregnancy
- A female of childbearing potential is any woman, regardless of sexual orientation
or whether they have undergone tubal ligation, who meets the following criteria:
1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been
naturally postmenopausal for at least 24 consecutive months (i.e., has had menses
at any time in the preceding 24 consecutive months)
- Women of childbearing potential and sexually active males must be strongly advised to
use an accepted and effective method of contraception or to abstain from sexual
intercourse for the duration of their participation in the study
- Patients must be able to swallow pills
- Patients must be able to tolerate CT or magnetic resonance (MR) imaging including
contrast agents as required for the treatment and the protocol
- Patients who are known to have human immunodeficiency virus (HIV) or are on
combination antiretroviral therapy are ineligible
We found this trial at
471
sites
600 S Santa Fe Ave
Salina, Kansas 67401
Salina, Kansas 67401
(785) 823-1521
Principal Investigator: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas, PA - Salina Dr. H.E. Hynes founded Cancer Center of Kansas,...
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330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Jennifer A. Chan
Phone: 877-726-5130
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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524 South Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 341-7654
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Andrew E. Hendifar
Phone: 310-423-8965
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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1111 Duff Ave
Ames, Iowa 50010
Ames, Iowa 50010
(866) 972-5477
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
McFarland Clinic PC-William R Bliss Cancer Center The William R. Bliss Cancer Center at Mary...
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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2000 E Greenville St
Anderson, South Carolina 29621
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: Jay B. Nayak
Phone: 864-512-1000
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Vaibhav Sahai
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Antioch, California 94531
Principal Investigator: Tatjana Kolevska
Phone: 510-891-3400
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Asheville, North Carolina 28803
Principal Investigator: Raymond Thertulien
Phone: 828-213-4150
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Auburn, California 95602
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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Auburn, California 95603
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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13001 E. 17th Pl.
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
Principal Investigator: Stephen Leong
Phone: 720-848-0650
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
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2000 Ogden Ave
Aurora, Illinois 60504
Aurora, Illinois 60504
(630) 978-6200
Principal Investigator: Kendrith M. Rowland
Phone: 630-978-6212
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
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Ballwin, Missouri 63011
Principal Investigator: Jay W. Carlson
Phone: 888-221-4849
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2401 W Belvedere Ave
Baltimore, Maryland 21215
Baltimore, Maryland 21215
(410) 601-9000
Principal Investigator: Marvin J. Feldman
Phone: 410-951-7950
Sinai Hospital of Baltimore Sinai Hospital of Baltimore provides a broad array of high-quality, cost-effective...
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401 North Broadway
Baltimore, Maryland 21287
Baltimore, Maryland 21287
410-955-5000
Principal Investigator: Ana D. De Jesus Acosta
Phone: 410-955-8804
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
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4305 New Shepherdsville Road
Bardstown, Kentucky 40004
Bardstown, Kentucky 40004
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Baton Rouge, Louisiana 70809
Principal Investigator: Robert A. Ramirez
Phone: 504-842-3708
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265 Fremont St
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
(269) 245-8166
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
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Beachwood, Ohio 44122
Principal Investigator: Jennifer R. Eads
Phone: 800-641-2422
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Beaver, Pennsylvania 15009
Principal Investigator: Nathan Bahary
Phone: 412-647-8073
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800 Farson Street
Belpre, Ohio 45714
Belpre, Ohio 45714
(740) 401-0417
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Strecker Cancer Center-Belpre The Memorial Health System's Strecker Cancer Center, Belpre combines the clinical expertise...
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1300 Anne Street NW
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
(218) 751-5430
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Sanford Clinic North-Bemidgi Sanford Health is a voluntary, not-for-profit health care organization. Through its entities,...
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Berkeley, California 94704
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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Billings, Montana 59101
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Saint Vincent Healthcare The Sisters of Charity of Leavenworth, Kansas, founded St. Vincent Healthcare in...
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300 N. Seventh St.
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
(701) 323-6000
Principal Investigator: Preston D. Steen
Phone: 712-252-0088
Sanford Bismarck Medical Center Whether your stay in our hospital is one day for same...
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1505 Eastland Drive
Bloomington, Illinois 61701
Bloomington, Illinois 61701
309-662-2102
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
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1501 North Oakland Drive
Bolivar, Missouri 65613
Bolivar, Missouri 65613
417-326-7200
Principal Investigator: Jay W. Carlson
Phone: 888-221-4849
Central Care Cancer Center at Carrie J. Babb Cancer Center Cancer treatment often requires a...
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Bonne Terre, Missouri 63628
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Boone, Iowa 50036
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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55 Fruit St
Boston, Massachusetts 02114
Boston, Massachusetts 02114
(617) 724-4000
Principal Investigator: Jennifer A. Chan
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center An integral part of one of the world
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450 Brookline Ave
Boston, Massachusetts 2215
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Jennifer A. Chan
Phone: 877-726-5130
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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915 Highland Blvd
Bozeman, Montana 59715
Bozeman, Montana 59715
(406) 414-5000
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Bozeman Deaconess Hospital Bozeman Deaconess Hospital is a Joint Commission certified, licensed Level III trauma...
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Branson, Missouri 65616
Principal Investigator: Jay W. Carlson
Phone: 888-221-4849
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Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Bryan, Texas 77802
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Burien, Washington 98166
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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1501 Trousdale Drive
Burlingame, California 94010
Burlingame, California 94010
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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Burlington, Wisconsin 53105
Principal Investigator: Antony Ruggeri
Phone: 414-649-5717
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201 E Nicollet Blvd
Burnsville, Minnesota 55337
Burnsville, Minnesota 55337
(952) 892-2000
Principal Investigator: David M. King
Phone: 952-993-1517
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
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400 South Clark Street
Butte, Montana 59701
Butte, Montana 59701
406-723-2500
Saint James Community Hospital and Cancer Treatment Center St. James Healthcare has played an important...
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Cameron Park, California 95682
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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210 W Walnut St
Canton, Illinois 61520
Canton, Illinois 61520
309-647-5240
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: James L. Wade
Phone: 309-243-3605
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
(573) 519-4725
Principal Investigator: James L. Wade
Phone: 309-243-3605
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
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Carbondale, Illinois 62902
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Carterville, Illinois 62918
Principal Investigator: James L. Wade
Phone: 309-243-3605
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160 S Adams St
Carthage, Illinois 62321
Carthage, Illinois 62321
(217) 357-6877
Principal Investigator: James L. Wade
Phone: 309-243-3605
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Castro Valley, California 94546
Principal Investigator: Jorge A. Garcia-Young
Phone: 415-209-2686
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Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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Centralia, Illinois 62801
Principal Investigator: James L. Wade
Phone: 309-243-3605
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Chadds Ford, Pennsylvania 19317
Principal Investigator: Gregory A. Masters
Phone: 302-733-6227
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505 S Plummer Ave
Chanute, Kansas 66720
Chanute, Kansas 66720
(620) 431-7580
Principal Investigator: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Chattanooga, Tennessee 37404
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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303 East Superior Street
Chicago, Illinois 60611
Chicago, Illinois 60611
Principal Investigator: Al B. Benson
Phone: 312-695-1301
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5841 S Maryland Ave
Chicago, Illinois 60637
Chicago, Illinois 60637
1-773-702-6180
Principal Investigator: Blase N. Polite
Phone: 773-834-7424
University of Chicago Comprehensive Cancer Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
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272 Hospital Rd
Chillicothe, Ohio 45601
Chillicothe, Ohio 45601
740-779-7500
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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12961 27th Ave
Chippewa Falls, Wisconsin 54729
Chippewa Falls, Wisconsin 54729
715-738-3700
Principal Investigator: Richard J. Mercier
Phone: 800-347-0673
Marshfield Clinic - Chippewa Center The 15,000 square foot Lake Hallie Center provides urgent care...
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Cincinnati, Ohio 45220
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Cincinnati, Ohio 45236
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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Cincinnati, Ohio 45242
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Cincinnati, Ohio 45247
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Cincinnati, Ohio 45255
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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10900 Euclid Ave
Cleveland, Ohio 44106
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Jennifer R. Eads
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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2500 Metrohealth Dr
Cleveland, Ohio 44109
Cleveland, Ohio 44109
(216) 778-7800
Principal Investigator: Bruce J. Averbook
Phone: 216-778-8526
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
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18101 Lorain Avenue
Cleveland, Ohio 44111
Cleveland, Ohio 44111
216.476.7000
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
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Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Clinton, North Carolina 28328
Principal Investigator: James N. Atkins
Phone: 252-399-7491
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Clive, Iowa 50325
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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12495 University Ave
Clive, Iowa 50325
Clive, Iowa 50325
(515) 358-9700
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
Mercy Cancer Center - West Lakes When it comes to cancer care, there
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Cody, Wyoming 82414
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Coeur d'Alene, Idaho 83814
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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6001 E Woodmen Rd
Colorado Springs, Colorado 80923
Colorado Springs, Colorado 80923
(719) 776-5000
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
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Colorado Springs, Colorado 80907
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Columbus, Ohio 43210
Principal Investigator: Manisha H. Shah
Phone: 800-293-5066
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Columbus, Ohio 43213
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
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Columbus, Ohio 43222
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
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5100 W Broad St
Columbus, Ohio 43228
Columbus, Ohio 43228
(614) 544-1000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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810 Jasonway Avenue
Columbus, Ohio 43214
Columbus, Ohio 43214
614/442-3130
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Columbus Oncology and Hematology Associates Inc Columbus Oncology and Hematology Associates is a group of...
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3535 Olentangy River Rd
Columbus, Ohio 43214
Columbus, Ohio 43214
(614) 566-5000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
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111 S Grant Ave
Columbus, Ohio 43215
Columbus, Ohio 43215
(614) 566-9000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Grant Medical Center Founded in 1900 in Columbus' downtown, Grant has grown into one of...
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3100 Plaza Properties Blvd
Columbus, Ohio 43219
Columbus, Ohio 43219
(614) 383-6000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
The Mark H. Zangmeister Center At The Zangmeister Center, we appreciate that our patients have...
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4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
Coon Rapids, Minnesota 55433
(763) 236-6000
Principal Investigator: David M. King
Phone: 952-993-1517
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
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Corbin, Kentucky 40701
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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