Bartonella in Liver Transplant Patients



Status:Recruiting
Conditions:Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:3/27/2019
Start Date:December 2013
End Date:December 2021
Contact:Marna E Ericson, phd
Email:erics004@umn.edu
Phone:6126242995

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Trial Summary
Trial Overview
Inclusion Criteria

Undetected Bartonella Spp. Infection Puts Liver Transplant Patients at Great Risk

Approximately 20 volunteers who have received a liver transplant and have been diagnosed with
cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be
analyzed for Bartonella spp..

Approximately 20 volunteers who have received a liver transplant and have been diagnosed with
cryptogenic cirrhosis will be included in this study. Blood samples will be analyzed for
Bartonella using the state-of-the art Bartonella Alpha Proteobacterium Growth Medium (BAPGM)
multi-platform testing, including liquid culture, enriched agar plating and molecular
techniques. Blood smears will be analyzed for intra-erythrocytic Bartonella spp.
Four-millimeter skin biopsies from non-lesional skin will be acquired from the same patients,
processed using our published techniques, and imaged using confocal microscopy and compared
to BAPGM test results. additionally, urine samples will be collected and analyzed for
microRNAs.

Inclusion Criteria:

- o Male and female subjects, ages 18 years and older

- Liver transplant recipient

- Diagnosis of cryptogenic cirrhosis

- Signed consent form

Exclusion Criteria:
We found this trial at
1
site
University of Minnesota Medical Center
Minneapolis, Minnesota 55455
Phone: 612-624-2995
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Minneapolis, MN
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