Feasibility and Safety of Functional Performance Testing in Patients Undergoing Hematopoietic Cell Transplantation

Inclusion Criteria:

- Patients with MSK histologically confirmed hematologic malignancy

- Scheduled for autologous or allogenic HCT at MSKCC

- ≥21 years old

- ECOG performance status of 0 or 1

- Completion of baseline CPET

- Willing to comply with protocol related procedures

Exclusion Criteria:

- Any of the following absolute contraindications to cardiopulmonary exercise testing

- Acute myocardial Infarction (within 3-5 days of any planned study procedures)

- Unstable angina

- Uncontrolled arrhythmia causing symptoms or hemodynamic compromise

- Recurrent syncope

- Active endocarditis

- Acute myocarditis or pericarditis

- Symptomatic severe aortic stenosis

- Uncontrolled heart failure

- Acute pulmonary embolus or pulmonary infarction within 3 months of any planned
study procedures

- Thrombosis of lower extremities

- Suspected dissecting aneurysm

- Uncontrolled asthma

- Pulmonary edema

- Respiratory failure

- Acute non-cardiopulmonary disorders that may affect exercise performance or be
aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis)

- Presence of any other concurrent, actively treated malignancy;

- History of any other malignancy treated within the past 3 years (other than
non-melanoma skin cancer);

- Room air desaturation at rest ≤85%

- Mental impairment leading to inability to cooperate