Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/1/2017 |
| Start Date: | October 2015 |
| End Date: | December 2017 |
| Contact: | Julianne C Kopf, BS |
| Email: | juliannekopf@gmail.com |
| Phone: | 402-801-2006 |
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals Through Intake of Whole Wheat Products in Comparison With Fruits and Vegetables
This study evaluates the impact of increased intake of fruits and vegetables and whole grains
on markers of inflammation and gut microbial composition. The treatment groups are 3 servings
of whole grain per day; 5 servings of fruits and vegetables per day; a combined 3 servings of
whole grain per day and 5 servings of fruits and vegetables per day; and a control (3
servings of refined grains per day provided).
on markers of inflammation and gut microbial composition. The treatment groups are 3 servings
of whole grain per day; 5 servings of fruits and vegetables per day; a combined 3 servings of
whole grain per day and 5 servings of fruits and vegetables per day; and a control (3
servings of refined grains per day provided).
Literature data suggests that fruits and vegetables and whole grains containing dietary fiber
and other nutrients are important for maintaining beneficial microbes in the gut. The
presence of beneficial microbes in the gut may mediate the subclinical inflammation
experienced in metabolic disease. In this project, overweight or obese participants with low
intakes of fruits and vegetables or whole grains will increase their intake of these foods to
recommended levels. Changes in markers of inflammation and gut microbiota composition will be
determined to assess and compare the potential impact of these foods on metabolic disease.
and other nutrients are important for maintaining beneficial microbes in the gut. The
presence of beneficial microbes in the gut may mediate the subclinical inflammation
experienced in metabolic disease. In this project, overweight or obese participants with low
intakes of fruits and vegetables or whole grains will increase their intake of these foods to
recommended levels. Changes in markers of inflammation and gut microbiota composition will be
determined to assess and compare the potential impact of these foods on metabolic disease.
Inclusion Criteria:
- Obese or overweight men or women (body mass index, BMI, ≥25 kg/m2)
- Free of known gastrointestinal disease
- No supplements use (excluding multivitamin)
- Participate in less than 1 h of exercise per week
- Have not taken antibiotics in the last six months
Exclusion Criteria:
- Men and women with fruits and vegetable intake exceeding 2 servings/day
- Men and women with whole grain intakes exceeding 1 serving/day
- Pregnant
- Do not fit the inclusion criteria
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