A Dose Escalation and Cohort-Expansion Study of Oral eFT508 in Subjects With Advanced Solid Tumors

eFT508 is an oral, potent and highly selective inhibitor of mitogen-activated protein kinase
interacting kinase (MNK) 1 and 2. Dysregulated translation of messenger RNA (mRNA) plays a
role in the pathogenesis of multiple solid tumors and hematological malignancies. MNK1 and
MNK2 integrate signals from several oncogenic and immune signaling pathways (including RAS,
p38 and Toll-like receptors) by phosphorylating eukaryotic initiation of factor 4E (eIF4E)
and key effector proteins. Phosphorylation of these regulatory proteins by MNK1 and MNK2
selectively regulates the stability and translation of a subset of cellular mRNA that control
tumor growth, the tumor microenvironment and immune signaling. Nonclinical studies indicate
that eFT508 shows activity against various types of solid tumors. These nonclinical studies
support initiation of clinical development of eFT508 in patients with cancer.

Inclusion Criteria:

1. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

2. Pathologically documented diagnosis of advanced solid tumor malignancy that progressed
after appropriate prior therapy or has no potential for cure with currently available
treatments.

3. Measurable disease defined by Response Evaluation Criteria in Solid Tumors (RECIST)
outside of any prior radiation field.

4. At least 3 weeks post any treatments/therapies at the time of first dose.

5. Adequate bone marrow function.

6. Adequate hepatic function.

7. Adequate renal function.

8. Normal coagulation panel.

9. Negative antiviral serology.

10. Willingness to use effective contraception.

Exclusion Criteria:

1. Known central nervous system malignancy.

2. Gastrointestinal disease that may interfere with drug absorption.

3. Significant cardiovascular disease.

4. Significant ECG abnormalities.

5. Ongoing risk of bleeding due to active peptic ulcer disease, bleeding diathesis, or
requirement for systemic anticoagulants. Use of heparin or thrombolytic agents for
local maintenance or clearance of a central venous catheter is permitted.

6. Ongoing systemic bacterial, fungal or viral infection (with the exception of fungal
infections of the skin or nails).

7. Pregnancy or breastfeeding.

8. Major surgery within 4 weeks before the start of study therapy.

9. Prior solid organ or bone marrow progenitor cell transplantation.

10. Prior therapy with any known inhibitor of MNK1 or MNK2.

11. Ongoing immunosuppressive therapy, including systemic or enteric corticosteroids (can
be using topical or inhaled corticosteroids).

12. Use of drugs that might pose a risk of a drug-drug interaction within 4-7 days before
the start of study therapy.