Photoacoustic Endoscopy of Barrett's Esophagus
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/27/2016 |
| Start Date: | August 2014 |
| End Date: | August 2016 |
| Contact: | Christine Frederiksen, M.S. |
| Email: | frederiksenc@wudosis.wustl.edu |
| Phone: | 314-362-2412 |
Endoscopy is an important technique in medicine to diagnose internal organs. Video endoscopy
has been the most common technique providing clear, real time video images of organs'
surfaces. However, this technique only images the surface and cannot effectively diagnose
diseased tissues that develop in endothelial tissues. Endoscopic ultrasound (EUS) has been
developed to overcome this limitation, and it is widely utilized in diagnosing GI diseases.
This technique can image very deep areas of organs, up to several centimeters; however, it
suffers from speckle artifacts and cannot adequately provide early diagnosis of tissue
abnormalities that do not show mechanical properties that differ significantly from those of
normal tissues.
The investigators propose that photoacoustic endoscopy (PAE), an endoscopic embodiment of
the rapidly growing photoacoustic tomography (PAT) technology, can fulfill the
aforementioned need.
has been the most common technique providing clear, real time video images of organs'
surfaces. However, this technique only images the surface and cannot effectively diagnose
diseased tissues that develop in endothelial tissues. Endoscopic ultrasound (EUS) has been
developed to overcome this limitation, and it is widely utilized in diagnosing GI diseases.
This technique can image very deep areas of organs, up to several centimeters; however, it
suffers from speckle artifacts and cannot adequately provide early diagnosis of tissue
abnormalities that do not show mechanical properties that differ significantly from those of
normal tissues.
The investigators propose that photoacoustic endoscopy (PAE), an endoscopic embodiment of
the rapidly growing photoacoustic tomography (PAT) technology, can fulfill the
aforementioned need.
Inclusion Criteria:
- Aged 18 years and older.
- Patients with Barrett's esophagus scheduled for esophageal surgery.
- Patients with GERD, but without Barrett's esophagus, scheduled for esophageal
surgery.
- Subjects must be able to understand and willing to sign a written informed consent
form.
Exclusion Criteria:
- Inability to give informed consent.
- Pregnancy.
- Age less than 18 years
- Previous esophageal procedure (surgery, photodynamic therapy, argon plasma
coagulation, endoscopic mucosal resection).
- Acute GI bleeding.
- Coagulopathy.
We found this trial at
1
site
St. Louis, Missouri 63108
Principal Investigator: Bryan F Meyers, M.D., M.P.H.
Phone: 314-362-8598
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