A Study to Evaluate the Adherence of 2 Strengths of Newly Manufactured Samples and Aged Samples of a New Formulation (JNJ-35685-AAA-G016 and JNJ-35685-AAA-G021) of Fentanyl Transdermal System Compared With Duragesic Fentanyl Transdermal Patch in Healthy Participants

This is a randomized (study medication assigned to participants by chance), single-center,
parallel-group single-application, modified 3-way crossover study. Each participant will
receive the marketed reference formulation (DURAGESIC) or the JNJ-35685-AAA-G016 or
JNJ-35685-AAA-G021 fentanyl transdermal system (TDS). The study consists of a screening
phase within 21 and 2 days before the first TDS application of the first period; a
partially-blinded treatment phase consisting of 3 single-application treatment periods; and
end-of-study or withdrawal assessments done upon completion of the 72-hour adhesion
assessment on Day 5 of Period 3 or upon withdrawal. A 7- to 16-day washout period will
separate the treatment periods, commencing at transdermal patch removal. The duration of
participation in the study for an individual participant will be 31 days to a maximum of 68
days (including screening and follow-up visits). Participants will be primarily evaluated
for cumulative adhesion percentage. Participants' safety will be monitored throughout the
study.

Inclusion Criteria:

- Participant must be healthy on the basis of physical examination, medical history,
vital signs, and 12-lead electrocardiogram (ECG) performed at screening. This
determination must be recorded in the participant's source documents and initialed by
the investigator

- A woman of childbearing potential must have a negative serum (beta-human chorionic
gonadotropin [beta-hCG]) test at screening and urine pregnancy test at Day -1 of the
first treatment period

- A man who is sexually active with a woman of childbearing potential and has not had a
vasectomy must agree to use a barrier method of birth control example, either condom
with spermicidal foam/gel/film/cream/suppository or partner with occlusive cap
(diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository,
and all men must also not donate sperm during the study and for 3 months after
completion of the study

- Participant must be willing and able to adhere to the prohibitions and restrictions
specified in this protocol

- Body mass index (BMI) between 18 and 30 kilogram per square meter (kg/m^2),
inclusive, and a body weight of not less than 50 kg

Exclusion Criteria:

- Participant has a history of or current clinically significant medical illness
including but not limited to, cardiac arrhythmias or other cardiac disease;
hematologic disease; coagulation disorders (including any abnormal bleeding or blood
dyscrasias); lipid abnormalities; significant pulmonary disease, including
bronchospastic respiratory disease; diabetes mellitus; hepatic or renal insufficiency
(creatinine clearance below 60 milliliter per minute [mL/min]); thyroid disease;
neurologic or psychiatric disease; infection; or any other illness that the
investigator considers should exclude the participant or that could interfere with
the interpretation of the study results

- Clinically significant abnormal values for hematology, clinical chemistry, or
urinalysis at screening as deemed appropriate by the investigator

- Clinically significant abnormal physical examination, vital signs or 12 lead ECG at
screening as deemed appropriate by the investigator

- Use of medications or treatments that would significantly influence or exaggerate
patch adhesion or that would alter inflammatory or immune response to the study
product (example antihistamines, systemic or topical corticosteroids, cyclosporine,
tacrolimus, cytotoxic drugs, immune globulin, Bacillus Calmette-Guerin (BCG),
monoclonal antibodies, radiation therapy)

- History of drug or alcohol abuse according to Diagnostic and Statistical Manual of
Mental Disorders (4th edition) criteria within 5 years before screening or positive
test result(s) for alcohol and/or drugs of abuse (such as barbiturates, opiates,
cocaine, cannabinoids, amphetamines, and benzodiazepines) at screening. Participants
must not use tobacco products, including all nicotine use, example, cigarettes,
cigars, chewing tobacco, patch, gum