Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours.

This study will attempt to determine the Maximum Tolerated Dose (MTD)/Recommended Phase 2
Dose (RP2D) of AZD1775 monotherapy when administered orally once daily (QD) or two times per
day (BID) on Days 1 to 5 followed by 9 days of rest in 14-day cycles, or QD on a 5/2 dosing
schedule (5 days on, followed by 2 days rest) in 21-day cycles in patients with locally
advanced or metastatic solid tumours. Both the QD 5/9 and 5/2 dosing schedules will run in
parallel. An evaluation will be made after the second QD cohort has been completed to
determine whether to proceed with one or both dosing schedules.

The AZD1775 MTD will be determined through dose-escalation using a 3+3 cohort design. If less
than one-third of evaluable patients in a given cohort (0 of 3 patients or 1 of 6 patients)
experiences a Dose-Limiting Toxicity (DLT); escalation may proceed to the next higher dose
level. If one of the first 3 patients enrolled in a given cohort experiences a DLT, 3
additional patents will be enrolled in that cohort. If a DLT is observed in one-third or more
of patients, the dose at which this occurs will be considered not tolerated and the MTD will
have been exceeded. The highest dose level(s) at which less than one-third of patients (0 of
3 patients or 1 of 6 patients) experiences a DLT will be declared the MTD. Up to 6 patients
will be enrolled in each cohort. Dose escalation will continue until identification of the
MTD or Sponsor termination of the study.

A maximum of 10 dose escalations are anticipated in the determination of MTD. Approximately 6
subjects may be added to replace non-evaluable patients. Therefore, a total of 66 patients
are expected to be treated.

Dose-limiting toxicities will be evaluated during Cycles 1 and 2 of treatment. If appropriate
the DLT observation period can be expanded by up to 2 weeks in case of treatment delay due to
study drug-related adverse events. Toxicity will be graded according to the National Cancer
Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.03. Patients
must complete Cycle 1 and Cycle 2 safety evaluations which will conclude on Cycle 3 Day 1,
and must receive at least 80% of the planned dose to be considered evaluable. Patients
receiving less than 80% of Cycle 1 and Cycle 2 dose (28 days) will be replaced unless they
experienced a confirmed DLT.

The patient population used to determine the MTD will consist of patients who have met the
minimum safety evaluation requirements of the study, and/or who have experienced a DLT in
Cycle 1 or Cycle 2. Minimum safety requirements will be met if during Cycle 1 and Cycle 2 of
treatment the patient receives a minimum of 80% of treatment doses of AZD1775, completes the
safety evaluations, and is observed for at least 28 days. Patients who do not meet these
minimum safety evaluation and treatment requirements and whom do not experience a DLT will be
replaced.

Patients will be allowed to continue treatment with AZD1775 until evidence of disease
progression, unacceptable toxicity, or other discontinuation criterion has occurred.

Inclusion Criteria:

1. Prior palliative radiation completed ≥ 7 days prior to the start of AZD1775 and
recovered from any acute adverse effects.

2. ECOG PS score 0 or 1.

3. Baseline laboratory values:

- ANC ≥1500/μL

- Hemoglobin (HgB) ≥9 g/dL

- Platelets ≥100,000/μL

- ALT and AST ≤3 x ULN or ≤5 x ULN if known hepatic metastases.

- Serum bilirubin WNL or ≤1.5 x ULN in patients with liver metastases; or total
bilirubin ≤3.0 x ULN with direct bilirubin WNL in patients with well documented
Gilbert's Syndrome.

- Serum creatinine ≤1.5 x ULN, or measured creatinine clearance ≥45 mL/min.

4. Females who are not of child-bearing potential and fertile females of child-bearing
potential who agree to use adequate contraceptive measures, who are not breastfeeding,
and who have a negative serum or urine pregnancy test within 3 days prior to, and on
the day of starting study treatment.

5. Males willing to use at least one medically acceptable form of contraception for
duration of study and for 3 months after treatment stops.

6. Predicted life expectancy ≥12 wks.

7. Age ≥18

8. Histologically or cytologically documented locally advanced or metastatic solid
tumour, excluding lymphoma, for which standard therapy does not exist or has proven
ineffective or intolerable.

9. Measurable or non-measurable disease according to RECIST v1.1.

Exclusion Criteria:

1. Use of a treatment drug 21 days or 5 half-lives (whichever is shorter) prior to
AZD1775. For drugs for which 5 half-lives is ≤21 days, a minimum of 10 days between
termination of the prior treatment and administration of AZD1775 treatment is
required.

2. Use of an investigational drug during the past 30 days or 5 half-lives (whichever is
longer) prior to first dose of study treatment.

3. Major surgical procedures ≤28 days of beginning study treatment, or minor surgical
procedures ≤7 days.

4. Grade >1 toxicity from prior therapy (except alopecia or anorexia).

5. Inability to swallow oral medications.

6. Palliative radiation therapy completed ≤7 days prior to start of study drug.

7. Known malignant CNS disease other than neurologically stable, treated brain
metastases.

8. Rx or non-Rx drugs or products known to be sensitive to CYP3A4 substrates or CYP3A4
substrates with a narrow therapeutic index, or to be moderate to strong
inhibitors/inducers of CYP3A4 which cannot be discontinued 2 weeks prior to dosing and
withheld until 2 weeks after the last dose of study drug.

9. Patients should stop using herbal medications 7 days prior to first dose of study
treatment.

10. Any of the following cardiac diseases currently or within the last 6 months as defined
by New York Heart Association (NYHA) ≥ Class 2.

- Unstable angina pectoris

- Congestive heart failure

- Acute myocardial infarction

- Conduction abnormality not controlled with pacemaker or medication

- Significant ventricular or supraventricular arrhythmias (patients with chronic
rate-controlled atrial fibrillation in the absence of other cardiac abnormalities
are eligible)

11. History of Torsades de pointes unless all risk factors that contributed to Torsades
have been corrected.

11. Mean resting QTc interval >470 msec (as calculated per institutional standards) at
study entry obtained from 3 ECGs within 5 minutes or congenital long QT syndrome.

12. Pregnant or lactating. 13. Serious active infection at the time of study entry, or
another serious underlying medical condition that would impair the ability of the patient
to receive study treatment.

14. Presence of other active invasive cancers. 15. Psychological, familial, sociological,
or geographical conditions that do not permit compliance with protocol.