Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Hematology |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/2/2019 |
| Start Date: | April 30, 2015 |
| End Date: | April 30, 2020 |
| Contact: | Eynav Klechevsky, Ph.D. |
| Email: | eklechevsky@wustl.edu |
| Phone: | 314-286-0897 |
Analysis of Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign
compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign
antigens, they migrate to secondary lymphoid organs, where the processed antigens are
presented to T cells.
Various DC subsets with unique cell lineages, surface protein markers, and tissue
localization determinants have been identified. For example, Langerhans cells (LCs) and
interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the
skin. Though both are expressed in the skin, they differ with respect to their origin and
surface protein content and can activate distinct types of immune responses. They may also
have different specificities for the capture of antigens and presentation to circulating T
cells.
To date, it is unknown what role, if any, the different DC populations that reside or
repopulate in the skin play in the development and progression of skin graft-versus-host
disease (GVHD) following bone marrow transplant.
compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign
antigens, they migrate to secondary lymphoid organs, where the processed antigens are
presented to T cells.
Various DC subsets with unique cell lineages, surface protein markers, and tissue
localization determinants have been identified. For example, Langerhans cells (LCs) and
interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the
skin. Though both are expressed in the skin, they differ with respect to their origin and
surface protein content and can activate distinct types of immune responses. They may also
have different specificities for the capture of antigens and presentation to circulating T
cells.
To date, it is unknown what role, if any, the different DC populations that reside or
repopulate in the skin play in the development and progression of skin graft-versus-host
disease (GVHD) following bone marrow transplant.
Inclusion Criteria:
- At least 18 years of age at enrollment
- Willing and able to sign the informed consent
- Current diagnosis/suspected diagnosis of acute skin GVHD OR Current
diagnosis/suspected diagnosis of chronic skin GVHD
Exclusion Criteria:
- Known infection with Hepatitis B or C, HTLV, or HIV
- Pregnant females
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Eynav Klechevsky, Ph.D.
Phone: 314-286-0897
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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