Observational Study Evaluating Long-Term Effectiveness of Duodopa/Duopa in Patients With Advanced Parkinson's Disease

Inclusion Criteria:

- Eligibility for Duodopa/Duopa therapy in accordance with the approved local
Duodopa/Duopa label in the participating country.

- Duodopa/Duopa naïve participants

- Decision to treat with Duodopa/Duopa made by the physician prior to any decision to
approach the participant to participate in this study

- Prior to any study-related procedures being performed, the participant, or legal
authorized representative (LAR) has voluntarily signed an Authorization for
Use/Disclosure of Data (AUDD)/informed consent form (ICF) according to national
regulations after the study has been explained and the subject has had the opportunity
to have questions answered.

Exclusion Criteria:

- Any condition included in the contraindications section of the approved local
Duodopa/Duopa label in the participating country.

- Participants who have had previous surgery for PD including, but not limited to deep
brain stimulation (DBS) or cell transplantation (this criterion removed for US sites).

- Participants currently in treatment with continuous apomorphine infusion. In case of a
previous treatment with continuous subcutaneous apomorphine infusion, there must be at
least 4 weeks between discontinuation of this treatment and inclusion into this study.

- Mini-Mental State Examination (MMSE) score <24

- Participation in a concurrent interventional clinical trial.

- Lack of motivation or insufficient language skills to complete the study
questionnaires