Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse

Inclusion Criteria:

- Male and females, aged 18-60 years;

- Good health as verified by screening examination;

- Able to read English and complete study evaluations;

- Able to provide informed written and verbal consent;

- AD sample must meet DSM-5 criteria for AUD as assessed using SCID-I and have positive
alcohol urine toxicology screens on admission to study; while HC group must never have
met criteria for AUD, with non-binging and nonhazardous alcohol intake levels( men:
below15 drinks/week; women: less than 8 drinks/week); and with negative alcohol urine
toxicology screens; Page

Exclusion Criteria:

- Meet current criteria for dependence on another psychoactive substance, excluding
nicotine; (ii) Current use of opiates or past history of opiate abuse/dependence;

- Regular use of anticonvulsants, sedatives/hypnotics, prescription analgesics, other
antihypertensives, anti-arrhythmics, antiretroviral medications, tricyclic
antidepressants, SSRI's naltrexone, antabuse;

- Psychotic or otherwise severely psychiatrically disabled (i.e., suicidal, homicidal,
current mania);

- Significant underlying medical conditions such as a history of seizure disorder,
cerebral, renal, thyroid or cardiac pathology which in the opinion of study physician
would preclude subjects from fully cooperating or be of potential harm during the
course of the study;

- Any psychotic disorder or current Axis I psychiatric symptoms (excluding anxiety
disorders) requiring specific attention, including need for psychiatric medications;

- hypotensive individuals with sitting blood pressure below 90/50 mmHG;

- Women who are pregnant, nursing or refuse to use a reliable form of birth control (as
assessed by pregnancy tests during initial medical evaluation, and assessed every two
weeks during the course of the study); and

- those with metal in their body excluded from MRI due to safety.