4D Phase Contrast MR: Hypertrophy in Liver Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Liver Cancer, Cancer, Cancer, Cancer, Cancer, Orthopedic |
| Therapuetic Areas: | Oncology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/1/2016 |
| Start Date: | August 2014 |
| End Date: | May 2017 |
| Contact: | Nael E Saad, M.D. |
| Email: | saadn@mir.wustl.edu |
| Phone: | 314-362-2900 |
4D Phase Contrast MR: Validation and Evaluation of Hypertrophy in Liver Cancer
The investigators hypothesize that 4Dimensional Phase Contrast Magnetic Resonance
Angiography (4D PC MRA) evaluation of portal venous flow predicts underlying liver function
and hypertrophic potential in patients with liver cancer presenting for portal vein
embolization (PVE). 4D PC MRA may provide a non-invasive measure of liver function that
could help determine which patients could safely and successfully undergo PVE and subsequent
resection of tumor. By comparing 4D PC MRA results with invasive catheter measurements the
investigators will validate the flow findings. Further regression/correlation analysis with
functional measures of the liver (HIDA scans), volumetrics, Doppler flow analysis,
histology, and outcomes will help the investigators to determine the ability of 4D PC MRA to
predict functional status and hypertrophic potential of the liver prior to PVE and
hepatectomy allowing for better patient selection and reduced morbidity/mortality.
Angiography (4D PC MRA) evaluation of portal venous flow predicts underlying liver function
and hypertrophic potential in patients with liver cancer presenting for portal vein
embolization (PVE). 4D PC MRA may provide a non-invasive measure of liver function that
could help determine which patients could safely and successfully undergo PVE and subsequent
resection of tumor. By comparing 4D PC MRA results with invasive catheter measurements the
investigators will validate the flow findings. Further regression/correlation analysis with
functional measures of the liver (HIDA scans), volumetrics, Doppler flow analysis,
histology, and outcomes will help the investigators to determine the ability of 4D PC MRA to
predict functional status and hypertrophic potential of the liver prior to PVE and
hepatectomy allowing for better patient selection and reduced morbidity/mortality.
Inclusion Criteria:
- Diagnosis of malignant liver tumor
- Clinically referred for portal vein embolization
- At least 18 years of age
- Willing and able to provide informed consent
Exclusion Criteria:
- Documented or reported contrast allergy
- Unable to receive or tolerate MRI scan after evaluation of MRI screening form
- GFR (glomerular filtration rate) < 30 on labs drawn within 6 weeks of imaging.
We found this trial at
1
site
St. Louis, Missouri 63108
Principal Investigator: Nael E Saad, M.D.
Phone: 314-362-2900
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