De Novo Lipogenesis of Sebaceous Glands in Acne
| Status: | Recruiting |
|---|---|
| Conditions: | Acne, Acne, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 15 - 45 |
| Updated: | 7/1/2018 |
| Start Date: | October 2015 |
| End Date: | May 2019 |
| Contact: | Raja K Sivamani, MD |
| Email: | rksivamani@ucdavis.edu |
| Phone: | 9167035145 |
There are two purposes of this study:
1. First, the investigators want to see what the differences are in de novo sebaceous lipid
production of people with and without acne.
2. Secondly, the investigators want to know what happens to sebaceous gland de novo lipid
production before and after treatment with topical tretinoin and oral isotretinoin.
1. First, the investigators want to see what the differences are in de novo sebaceous lipid
production of people with and without acne.
2. Secondly, the investigators want to know what happens to sebaceous gland de novo lipid
production before and after treatment with topical tretinoin and oral isotretinoin.
The primary objective of this study is to understand how de novo lipid production of
sebaceous glands are altered in acne and with acne directed therapy.
Hypothesis 1: The overall de novo lipogenesis will be increased in those with acne
Hypothesis 2: Treatment with topical tretinoin and systemic isotretinoin will reduce de novo
lipogenesis.
sebaceous glands are altered in acne and with acne directed therapy.
Hypothesis 1: The overall de novo lipogenesis will be increased in those with acne
Hypothesis 2: Treatment with topical tretinoin and systemic isotretinoin will reduce de novo
lipogenesis.
Inclusion Criteria:
- Age 15 to 45 years of age
- Subject/Parents/Legal Guardian be able to read and comprehend study procedure and
consent forms
- Have acne that is diagnosed by a board certified dermatologist
- Meet one of the following criteria:
- already been prescribed oral isotretinoin for treatment of acne
- have already been prescribed a topical retinoid
- eligible for prescription of topical tretinoin
Exclusion Criteria:
- Those who have already initiated or completed a course of systemic isotretinoin
- Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome
- Those who are pregnant in female participants
- Those who do not fit the inclusion criteria
We found this trial at
2
sites
Davis, California 95616
Principal Investigator: Raja K Sivamani, MD
Phone: 916-734-1509
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