Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty
| Status: | Recruiting |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA), Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 8/20/2016 |
| Start Date: | November 2015 |
| Contact: | Eric Silverman, MD |
| Phone: | 518-262-4300 |
Prospective, Randomized, Double-Blinded, Allocation Concealed Study Comparing the Efficacy of Liposomal Bupivacaine Over Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Primary Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and duration of pain relief after total
knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus
standard bupivacaine with an adjuvant, dexamethasone when administered as a quadriceps
sparing femoral nerve block and periarticular injection. It is hypothesized that liposomal
bupivacaine is superior to standard bupivacaine with dexamethasone and will decrease time to
discharge readiness.
knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus
standard bupivacaine with an adjuvant, dexamethasone when administered as a quadriceps
sparing femoral nerve block and periarticular injection. It is hypothesized that liposomal
bupivacaine is superior to standard bupivacaine with dexamethasone and will decrease time to
discharge readiness.
Inclusion Criteria:
- Adult patients of American Society of Anesthesiologist (ASA) I-III physical class
with a pre-operative diagnosis of primary osteoarthritis scheduled for elective
primary total knee arthroplasty.
- Patients must be living independently at home prior to undergoing primary total knee
arthroplasty with intention of discharge directly to home after hospitalization
Exclusion Criteria:
- Subjects will not be eligible for this trial if they have a history of allergy to a
local anesthetic
- Known peripheral neuropathy
- Known connective tissue or immunological disorders
- Stroke or other known central nervous system disorders
- Renal dysfunction
- Hepatic dysfunction
- Cardiac dysfunction other than hypertension
- Pregnant subjects
- Immunosuppression
- Human immunodeficiency virus (HIV)
- Alcohol or drug abuse
- Chronic pain or opioid dependence
- Coagulopathy or those unable to comply with study requirements.
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