An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Liver Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/3/2019 |
| Start Date: | November 25, 2015 |
| End Date: | July 14, 2020 |
A Randomized, Multi-center Phase III Study of Nivolumab Versus Sorafenib as First-Line Treatment in Patients With Advanced Hepatocellular Carcinoma (CheckMate 459: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 459)
The purpose of this study is to determine if nivolumab or sorafenib is more effective in the
treatment of Advanced Hepatocellular Carcinoma.
treatment of Advanced Hepatocellular Carcinoma.
For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- Histologically confirmed advanced hepatocellular carcinoma, not eligible for surgical
and/or locoregional therapies; or progressive disease after surgical and /or
locoregional therapies
- Locoregional therapy for hepatocellular carcinoma (HCC) must be completed at least 4
weeks prior to the baseline scan
- Child-Pugh Class A
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1
Exclusion Criteria:
- Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
- Prior liver transplant
- Active, known, or suspected autoimmune disease
We found this trial at
18
sites
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1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
Phone: 205-975-9564
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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5801 South Ellis Avenue
Chicago, Illinois 60637
Chicago, Illinois 60637
773.702.1234
Phone: 773-702-4193
University of Chicago One of the world's premier academic and research institutions, the University of...
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825 Eastlake Ave E
Seattle, Washington 98109
Seattle, Washington 98109
(206) 288-7222
Phone: 206-288-6439
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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2201 Inwood Rd
Dallas, Texas 75235
Dallas, Texas 75235
(214) 645-8300
Phone: 214-648-4180
U.T. Southwestern Medical Center The story of UT Southwestern Medical Center is one of commitment...
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University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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1428 Madison Ave
New York, New York 10029
New York, New York 10029
(212) 241-6500
Phone: 212-284-7876
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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111 S 11th St
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
(215) 955-6000
Phone: 215-955-6033
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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