Evaluation of Efficay & Safety of Galcanezumab in the Prevention of Episodic Migraine- the EVOLVE-2 Study
| Status: | Completed |
|---|---|
| Conditions: | Migraine Headaches |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/9/2019 |
| Start Date: | December 4, 2015 |
| End Date: | October 5, 2018 |
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Migraine - the EVOLVE-2 Study
The main purpose of this study is to evaluate the efficacy and safety of the study drug known
as galcanezumab in participants with episodic migraine.
as galcanezumab in participants with episodic migraine.
Inclusion Criteria:
- Have a diagnosis of migraine as defined by International Headache Society (IHS)
International Classification of Headache Disorders (ICHD)-3 beta version (1.1 or 1.2)
(ICHD-3 2013), with a history of migraine headaches of at least 1 year prior to
screening, migraine onset prior to age 50 and MONTHLY frequency of 4-14 MHD.
Exclusion Criteria:
- Are currently enrolled in or have participated within the last 30 days or within 5
half-lives (whichever is longer) in a clinical trial involving an investigational
product.
- Current use or prior exposure to galcanezumab or another Calcitonin Gene-Related
Peptide (CGRP) antibody.
- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins, or to galcanezumab.
- History of persistent daily headache, cluster headache or migraine subtypes including
hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
We found this trial at
50
sites
Farmington Hills, Michigan 48334
Principal Investigator: Aaron Ellenbogen
Phone: 248-957-8940
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Steven Graff-Radford
Phone: 310-423-9616
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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1709 S Rock Rd
Wichita, Kansas 67207
Wichita, Kansas 67207
316-689-6629
Principal Investigator: Timothy Koehler
Phone: 316-462-0426
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Akron, Ohio 44320
Principal Investigator: Jose Rafecas
Phone: 330-572-1011
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Albuquerque, New Mexico
Principal Investigator: Marigene Sharma
Phone: 505-224-7407
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811 Juniper St NE
Atlanta, Georgia 30308
Atlanta, Georgia 30308
(404) 881-5800
Principal Investigator: Robert Riesenberg
Phone: 404-881-5800
Atlanta Center for Medical Research Welcome to the Atlanta Center for Medical Research, a leader...
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Bellevue, Washington 98007
Principal Investigator: Arifulla Khan
Phone: 425-453-0404
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Binghamton, New York 13760
Principal Investigator: DUNCAN SZE-TU
Phone: 607-754-3863
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Brooklyn, New York 11235
Principal Investigator: Nicholas Vatakis
Phone: 708-616-2230
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Centennial, Colorado 80112
Principal Investigator: Itay Melamed
Phone: 303-771-9000
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Chicago, Illinois 60614
Principal Investigator: Alexander Feoktistov
Phone: 773-388-6390
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Cincinnati, Ohio 45267
Principal Investigator: Lesley Arnold
Phone: 513-558-4622
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Columbus, Ohio 43214
Principal Investigator: Jeffrey White
Phone: 614-263-4400
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801 Monterey Street
Coral Gables, Florida 33134
Coral Gables, Florida 33134
Principal Investigator: Jeffrey Rosen
Phone: 305-445-5637
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Dayton, Ohio 45432
Principal Investigator: Steve Choi
Phone: 937-912-4367
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Greer, South Carolina 29651
Principal Investigator: Thomas Ballard
Phone: 864-334-0141
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Hazelwood, Missouri 63042
Principal Investigator: Larry Reed
Phone: 314-972-9600
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High Point, North Carolina 27265
Principal Investigator: Margarita Nunez
Phone: 336-841-0700
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Hollywood, Florida 33021
Principal Investigator: Harvey Schwartz
Phone: 954-366-0277
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Houston, Texas 77074
Principal Investigator: Alan Reichman
Phone: 713-484-6947
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Indianapolis, Indiana 46256
Principal Investigator: KRISTI GEORGE
Phone: 317-537-6060
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Jacksonville, Florida 32205
Principal Investigator: Herman Downey
Phone: 904-693-1490
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Jacksonville, Florida 32216
Principal Investigator: Nandita Joshi
Phone: 904-281-5757
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Las Vegas, Nevada 89113
Principal Investigator: Abraham Nagy
Phone: 702-749-7147
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Middleton, Wisconsin 53562
Principal Investigator: RISE FUTTERER
Phone: 608-827-2316
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Montclair, California 91763
Principal Investigator: Mia Moon
Phone: 909-203-4706
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Mount Pleasant, South Carolina 29464
Principal Investigator: Cynthia Strout
Phone: 843-856-3784
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New Bedford, Massachusetts 02740
Principal Investigator: Mushtaque Chachar
Phone: 508-990-9555
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Newport News, Virginia 23606
Principal Investigator: Chester Fisher
Phone: 757-591-8100
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Oakland, California 94612
Principal Investigator: Ira Glick
Phone: 510-444-2877
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Oklahoma City, Oklahoma 73103
Principal Investigator: Louise Thurman
Phone: 405-235-8188
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Philadelphia, Pennsylvania 19114
Principal Investigator: Eugene Andruczyk
Phone: 215-676-6696
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Phoenix, Arizona 85004
Principal Investigator: Joshua Tobin
Phone: 602-265-6500
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Phoenix, Arizona 85023
Principal Investigator: Louise Taber
Phone: 623-414-4022
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Salt Lake City, Utah 84109
Principal Investigator: Dan Henry
Phone: 801-486-3021
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San Diego, California 92108
Principal Investigator: William Koltun
Phone: 619-521-2830
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San Francisco, California 94102
Principal Investigator: Shawn Hassler
Phone: 415-423-4055
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Sherman Oaks, California 91403
Principal Investigator: Jose Itzcovich-Schuster
Phone: 818-788-0746
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Springfield, Oregon 97477
Principal Investigator: Miguel Estevez
Phone: 541-868-9430
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Toms River, New Jersey 08755
Principal Investigator: Ashok Patel
Phone: 732-244-2299
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Virginia Beach, Virginia 23456
Principal Investigator: Amelito Malapira
Phone: 757-507-0607
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Waxahachie, Texas 75165
Principal Investigator: Thomas Ledbetter
Phone: 972-961-3949
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