Evaluation of Galcanezumab in the Prevention of Chronic Migraine



Status:Active, not recruiting
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 65
Updated:1/9/2019
Start Date:November 30, 2015
End Date:May 3, 2021

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Chronic Migraine - the REGAIN Study

The main purpose of this study is to evaluate the efficacy of the study drug known as
galcanezumab in participants with chronic migraine.


Inclusion Criteria:

- Have a diagnosis of chronic migraine as defined by International Headache Society
(IHS) International Classification of Headache Disorders (ICHD)-3 beta guidelines
(1.3) (ICHD-3 2013), with a history of migraine headaches of at least 1 year prior to
screening, and migraine onset prior to age 50.

Exclusion Criteria:

- Are currently enrolled in or have participated within the last 30 days or within 5
half-lives (whichever is longer) in a clinical trial involving an investigational
product.

- Current use or prior exposure to galcanezumab or another calcitonin gene-related
peptide (CGRP) antibody.

- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins, or to galcanezumab.

- History of persistent daily headache, cluster headache or migraine subtypes including
hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
We found this trial at
53
sites
Associated Neurologists of Southern Connecticut, PC
Fairfield, Connecticut 06824
Principal Investigator: Dario Zagar
Phone: 203-333-1151
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
Principal Investigator: Bruce Rankin
Phone: 386-740-0070
Site Overview Avail Clinical Research is a renowned and experienced clinical research site conducting Phase...
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Renstar Medical Research
104 SE 1st Avenue
Ocala, Florida 34471
352-629-5800
Principal Investigator: Sidney Clevinger
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Heartland Research Associates, LLC
1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
Principal Investigator: Timothy Koehler
Phone: 316-462-0426
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Albuquerque Clinical Trials
Albuquerque, New Mexico
Principal Investigator: Marigene Salazar Sharma
Phone: 505-224-7407
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Dent Neurological Institute
Amherst, New York 14226
Principal Investigator: Laszlo Mechtler
Phone: 716-558-5670
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Michigan Head Pain & Neurological Institute
Ann Arbor, Michigan 48104
Principal Investigator: Joel Saper
Phone: 734-677-6000
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Ann Arbor, MI
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FutureSearch Trials of Neurology and Sleep Lab
Austin, Texas 78731
Principal Investigator: John Hudson
Phone: 512-380-9925
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Austin, TX
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Pharmasite Research
Baltimore, Maryland 21208
Principal Investigator: Alan Jonas
Phone: 410-602-1440
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Northwest Clinical Research Center
Bellevue, Washington 98007
Principal Investigator: Arifulla Khan
Phone: 425-453-0404
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Northwest Clinical Trials
Boise, Idaho 83704
Principal Investigator: Brock McConnehey
Phone: 208-685-0600
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Boston Clinical Trials, INC.
Boston, Massachusetts 02135
Principal Investigator: Arkadiy Stolyar
Phone: 617-477-4868
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Clinical Trial Facility in Buenos Aires
Buenos Aires,
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Christie Clinic
Champaign, Illinois 61820
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Clinical Trials of South Carolina
Charleston, South Carolina 29406
Principal Investigator: David Stickler
Phone: 843-725-5067
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ClinSearch, LLC
Chattanooga, Tennessee 37421
Principal Investigator: Richard Krause Krause
Phone: 423-698-4584
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University of Cincinnati College of Medicine
Cincinnati, Ohio 45267
Principal Investigator: Lesley Arnold
Phone: 513-558-4622
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University of South Carolina
Columbia, South Carolina 29208
Principal Investigator: Xiao Androulakis
Phone: 803-545-6089
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Headache Medicine Specialist of North Texas
Dallas, Texas 75231
Principal Investigator: George Nissan
Phone: 214-820-9272
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Pharmacology Research Institute, Encino
Encino, California 91316
Principal Investigator: DANIEL GROSZ
Phone: 818-705-7450
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Colorado Neurological Institute
Englewood, Colorado
Principal Investigator: Cori Millen
Phone: 720-336-4300
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Advanced Neurosciences Research, LLC
Fort Collins, Colorado 80528
Principal Investigator: Tamara Miller
Phone: 970-226-6111
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Fullerton Neurology and Headache Center
Fullerton, California 92835
Principal Investigator: Jack Florin
Phone: 714-738-3845
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Healthcare Research Network - Hazelwood
Hazelwood, Missouri 63042
Principal Investigator: Larry Reed
Phone: 314-972-9600
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Midwest Institute for Clinical Research
Indianapolis, Indiana 46260
Principal Investigator: Phillip Toth
Phone: 317-705-7050
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Clinical Neuroscience Solutions, Inc.
Jacksonville, Florida 32216
Principal Investigator: Nandita Joshi
Phone: 904-281-5757
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Pharmacology Research Institute, Los Alamitos
Los Alamitos, California 90720
Principal Investigator: Nader Oskooilar
Phone: 714-827-3668
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Dean Foundation For Health Research & Education
Middleton, Wisconsin 53562
Principal Investigator: RISE FUTTERER
Phone: 608-827-2316
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Clinical Research Institute Inc.
Minneapolis, Minnesota 55402
Principal Investigator: Gary Berman
Phone: 612-333-2200
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Coastal Carolina Research Center
Mount Pleasant, South Carolina 29464
Principal Investigator: Cynthia Strout
Phone: 843-856-3784
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Pharmacology Research Institute, Newport Beach
Newport Beach, California 92660
Principal Investigator: Don De Francisco
Phone: 949-752-7910
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Health Research of Hampton Roads
Newport News, Virginia 23606
Principal Investigator: Chester Fisher
Phone: 757-591-8100
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Psychiatric Inst of Florida-Clinical Neuroscience Solutions
Orlando, Florida 32801
Principal Investigator: Linda Harper
Phone: 407-425-5100
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Compass Research
Oviedo, Florida 32765
Principal Investigator: Bradley Block
Phone: 407-678-6888
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21st Century Neurology
Phoenix, Arizona 85004
Principal Investigator: Joshua Tobin
Phone: 602-265-6500
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Arizona Research Center
Phoenix, Arizona 85023
Principal Investigator: Louise Taber
Phone: 623-414-4022
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Island Neuro Associates,PC
Plainview, New York 11803
Principal Investigator: Ira Turner
Phone: 516-822-2230
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Preferred Primary Care Physicians
Pleasant Hills, Pennsylvania 15236
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Phoenix Medical Research
Prairie Village, Kansas 66206
Principal Investigator: Haydn Thomas
Phone: 913-381-7180
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Desert Valley Research
Rancho Mirage, California 92270
Principal Investigator: Dennis Anderson
Phone: 760-464-0470
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Anderson Clinical Research
Redlands, California 92374
Principal Investigator: Donald Anderson
Phone: 909-792-9007
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Robbins Headache Clinic
Riverwoods, Illinois 60015
Principal Investigator: Lawrence Robbins
Phone: 847-374-9399
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Foothill Family Clinic
Salt Lake City, Utah 84109
Principal Investigator: Dan Henry
Phone: 801-486-3021
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Artemis Institute for Clinical Research
San Diego, California 92123
Principal Investigator: Vishaal Mehra
Phone: 858-278-3647
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Medical Center for clinical research
San Diego, California 92108
Principal Investigator: William Koltun
Phone: 619-521-2830
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Optimus Medical Group
San Francisco, California 94102
Principal Investigator: Shawn Hassler
Phone: 415-518-1292
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BG Neurology
Spartanburg, South Carolina 29307
Principal Investigator: Bogdan Gheorghiu
Phone: 864-577-9107
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Premier Clinical Research
Spokane, Washington 99204
Principal Investigator: David Greeley
Phone: 509-343-3710
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Clinvest
Springfield, Missouri 65807
Principal Investigator: Timothy Smith
Phone: 417-883-7889
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Healthcare Research Consultant
Tulsa, Oklahoma 74135
Principal Investigator: Jay Johnson
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Sentara Neurology Specialists
Virginia Beach, Virginia 23456
Principal Investigator: Amelito Malapira
Phone: 757-507-0607
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Premiere Research Institute at Palm Beach Neurology
West Palm Beach, Florida 33407
Principal Investigator: Paul Winner
Phone: 561-845-0500
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Abington Neurological Associates
Willow Grove, Pennsylvania 19090
Principal Investigator: Brad Klein
Phone: 215-957-9250
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