Efficacy and Safety of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Seasonal Allergic Rhinitis (SAR)

Inclusion Criteria:

1. Aged 12 years and older inclusive of either sex.

2. Documented clinical history of SAR (for at least 2 years preceding the Screening Visit
[Visit 1]) with exacerbations (clinical evidence of active symptoms) during the spring
allergy season (tree/grass pollen)

3. A 12-hour reflective TNSS ≥ 8 out of a possible 12 and a congestion score of ≥ 2 for
the AM assessment at the Screening Visit (Visit 1).

Exclusion Criteria:

1. Pregnant or lactating women.

2. Plans to travel outside the known pollen area for the investigative site for > 24
hours during the last 7 days of run in period.

3. History of anaphylaxis and/or other severe local reaction(s) to skin testing.

4. History of positive test for HIV, Hepatitis B or Hepatitis C infection.

5. Documented evidence of acute or significant chronic sinusitis or chronic purulent
postnasal drip.

6. Subjects with an active pulmonary disorder or infection.

7. Subjects with posterior subcapsular cataracts or glaucoma