Wearable Technology to Reduce Sedentary Behavior and CVD Risk in Older Adults

A recruitment of 40 sedentary men and women ≥ 60 years of age with elevated cardiovascular
risk and follow them for 20 weeks. Participants will be randomly assigned (n = 20/group) to
1) an 8-week, twice-weekly, multi-modal, center-based exercise intervention (EX) followed by
12 additional weeks of follow-up assessment, or 2) the same intervention with participants
also asked to wear a validated lightweight activity tracker on their hip during waking hours
and instructed on how to reduce sedentary behavior increase NEPA within their daily routines
(EX + NEPA). Evaluations will be done to 1) the extent to which EX + NEPA modifies sedentary
behavior, 2) the impact of the interventions on cardiovascular risk factors, including blood
pressure, exercise capacity, waist circumference, and circulating biomarkers, and 3) develop
and optimize study procedures to guide the future trial.

Inclusion Criteria:

- Sedentary lifestyle, defined as <150 min/wk of moderate physical activity by CHAMPS
questionnaire

- Moderate to high-risk of CHD events according to ATP-III risk classification algorithm

- Willingness to be randomized to either intervention group

- Willingness to participate in all study procedures

Exclusion Criteria:

- Failure to provide informed consent;

- Regular participation in an exercise training program within the last 3 months

- Absolute contraindication(s) to exercise training (American College of Sports Medicine
guidelines)

- Office SBP > 180 mm Hg or DBP > 110 mm Hg

- Severe cardiac disease, i.e. NYHA Class III or IV congestive heart failure, clinically
significant aortic stenosis, history of cardiac arrest, use of a cardiac
defibrillator, or uncontrolled angina;

- Myocardial infarction or stroke within past year

- Significant cognitive impairment, i.e. known dementia or a Mini-Mental State
Examination score < 24

- Progressive, degenerative neurologic disease, e.g., Parkinson's Disease, multiple
sclerosis, ALS;

- Severe rheumatologic/orthopedic disease, e.g., awaiting joint replacement, active
inflammatory disease

- Severe pulmonary disease, requiring either steroid pills or injections or the use of
supplemental oxygen;

- Hip fracture, hip or knee replacement, or spinal surgery within past 4 months;

- Other significant co-morbid conditions that would impair ability to participate in the
intervention

- Simultaneous participation in another intervention trial