A Study of ALKS 3831 in Adults With Acute Exacerbation of Schizophrenia (the ENLIGHTEN-1 Study)

Inclusion Criteria:

- Has a body mass index (BMI) of 18.0 - 40.0 kg/m^2

- Meets criteria for the diagnosis of schizophrenia

- Resides in a stable living situation when not hospitalized

- Is willing and able to provide government-issued identification

- Additional criteria may apply

Exclusion Criteria:

- Has had a psychiatric hospitalization for more than 30 days during the 90 days before
screening

- Subject initiated first antipsychotic treatment within the past 12 months, or <1 year
has elapsed since the initial onset of active-phase of schizophrenia symptoms

- Subject poses a current suicide risk

- Subject has a history of treatment resistance

- Subject has a history of poor or inadequate response to treatment with olanzapine

- Subject requires or has had electroconvulsive therapy (ECT) treatment in the 2-month
period prior to screening

- Subject has a diagnosis of moderate or severe alcohol or drug use disorder

- Subject has a positive urine drug screen for opioids, amphetamine/methamphetamine,
phencyclidine, or cocaine at screening

- Additional criteria may apply