Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer
Status: | Recruiting |
---|---|
Conditions: | Lung Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 1/31/2019 |
Start Date: | December 2015 |
End Date: | April 2027 |
Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer
This randomized phase II/III trial studies how well whole-brain radiation therapy works and
compares it with or without hippocampal avoidance in treating patients with small cell lung
cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only
(limited stage) or has spread outside of the lung in which it began or to other parts of the
body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and
shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding
the hippocampus during whole-brain radiation could decrease the chance of side effects on
memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more
effective with or without hippocampal avoidance in treating patients with small cell lung
cancer.
compares it with or without hippocampal avoidance in treating patients with small cell lung
cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only
(limited stage) or has spread outside of the lung in which it began or to other parts of the
body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and
shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding
the hippocampus during whole-brain radiation could decrease the chance of side effects on
memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more
effective with or without hippocampal avoidance in treating patients with small cell lung
cancer.
PRIMARY OBJECTIVES:
I. Determine whether the 12-month intracranial relapse rate following hippocampal avoidance
(HA)-prophylactic cranial irradiation (PCI) is non-inferior compared to the rate following
PCI for patients with small cell lung cancer (SCLC). (Randomized Phase II Component
[Non-Inferiority]) II. Determine whether HA-PCI reduces the likelihood of 6-month
deterioration from baseline in Hopkins Verbal Learning Test (HVLT)-Revised (R) delayed recall
compared to PCI for patients with SCLC. (Phase III Component [Efficacy])
SECONDARY OBJECTIVES:
I. Compare time to cognitive failure, as measured by a battery of tests (HVLT-R, Controlled
Oral Word Association [COWA] test, and Trail Making Test [TMT] parts A and B), after PCI
versus HA-PCI in SCLC.
II. Compare time to cognitive failure as separately measured by each test (HVLT-R for Total
Recall and Delayed Recognition, COWA test, and TMT parts A and B), after PCI versus HA-PCI
for SCLC.
III. Compare patient-reported cognitive functioning and other quality of life domains
(assessed by the European Organization for Research and Treatment of Cancer [EORTC] Quality
of Life Questionnaire [QLQ]-Core [C]30 and BN20) between PCI versus HA-PCI for patients with
SCLC.
IV. Compare overall survival after PCI versus HA-PCI for patients with SCLC. V. Compare
12-month intracranial relapse rate (at completion of phase III) and time to intracranial
relapse after PCI versus HA-PCI for patients with SCLC.
VI. Evaluate adverse events according to Common Terminology Criteria for Adverse Events
(CTCAE) criteria.
VII. Correlate changes in health-related quality of life (HRQOL) domains with changes in
cognitive testing outcomes following PCI versus HA-PCI for patients with SCLC.
VIII. Assess cost-effectiveness of HA-PCI (intensity modulated radiation therapy [IMRT]) and
PCI (3-dimensional conformal radiation therapy [3DCRT]) using the EuroQual (EQ)-5-Dimensions
(5D)-5L.
TERTIARY OBJECTIVES:
I. Collect serum, whole blood, and urine for future translational research analyses.
II. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and
hippocampal volumetry as potential predictors of cognitive decline and differential benefit
from HAPCI as compared to PCI.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients undergo PCI using 3DCRT daily for 2 weeks.
ARM II: Patients undergo PCI with HA using IMRT daily for 2 weeks.
After completion of study treatment, patients are followed every 3 months for 1 year, then
every 6 months until 3 years and then annually until death.
I. Determine whether the 12-month intracranial relapse rate following hippocampal avoidance
(HA)-prophylactic cranial irradiation (PCI) is non-inferior compared to the rate following
PCI for patients with small cell lung cancer (SCLC). (Randomized Phase II Component
[Non-Inferiority]) II. Determine whether HA-PCI reduces the likelihood of 6-month
deterioration from baseline in Hopkins Verbal Learning Test (HVLT)-Revised (R) delayed recall
compared to PCI for patients with SCLC. (Phase III Component [Efficacy])
SECONDARY OBJECTIVES:
I. Compare time to cognitive failure, as measured by a battery of tests (HVLT-R, Controlled
Oral Word Association [COWA] test, and Trail Making Test [TMT] parts A and B), after PCI
versus HA-PCI in SCLC.
II. Compare time to cognitive failure as separately measured by each test (HVLT-R for Total
Recall and Delayed Recognition, COWA test, and TMT parts A and B), after PCI versus HA-PCI
for SCLC.
III. Compare patient-reported cognitive functioning and other quality of life domains
(assessed by the European Organization for Research and Treatment of Cancer [EORTC] Quality
of Life Questionnaire [QLQ]-Core [C]30 and BN20) between PCI versus HA-PCI for patients with
SCLC.
IV. Compare overall survival after PCI versus HA-PCI for patients with SCLC. V. Compare
12-month intracranial relapse rate (at completion of phase III) and time to intracranial
relapse after PCI versus HA-PCI for patients with SCLC.
VI. Evaluate adverse events according to Common Terminology Criteria for Adverse Events
(CTCAE) criteria.
VII. Correlate changes in health-related quality of life (HRQOL) domains with changes in
cognitive testing outcomes following PCI versus HA-PCI for patients with SCLC.
VIII. Assess cost-effectiveness of HA-PCI (intensity modulated radiation therapy [IMRT]) and
PCI (3-dimensional conformal radiation therapy [3DCRT]) using the EuroQual (EQ)-5-Dimensions
(5D)-5L.
TERTIARY OBJECTIVES:
I. Collect serum, whole blood, and urine for future translational research analyses.
II. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and
hippocampal volumetry as potential predictors of cognitive decline and differential benefit
from HAPCI as compared to PCI.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients undergo PCI using 3DCRT daily for 2 weeks.
ARM II: Patients undergo PCI with HA using IMRT daily for 2 weeks.
After completion of study treatment, patients are followed every 3 months for 1 year, then
every 6 months until 3 years and then annually until death.
Inclusion Criteria:
- PRIOR TO STEP 1 REGISTRATION
- Histologic proof or unequivocal cytologic proof (fine needle aspiration, biopsy or two
positive sputa) of SCLC within 250 days prior to Step 1 registration
- Patients must have a three-dimensional (3D), T1-weighted, spoiled gradient (SPGR),
magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI
scan without and with gadolinium contrast-enhanced T1-weighted axial, coronal, and
sagittal sequence acquisitions and standard T2-weighted axial and coronal fluid
attenuation inversion recovery (FLAIR) sequence acquisitions within 28 days of Step 1
registration; to yield acceptable image quality, the pre-contrast-enhanced should have
a resolution of 1 x 1 x 1.2 mm and should follow the protocols established by the
Alzheimer's Disease Neuroimaging Initiative (ADNI); performance of this sequence at a
3 Tesla field strength is recommended; sites may contact the Imaging Co-Chair, Dr.
Tammie Benzinger, for further information or assistance if needed; to yield acceptable
image quality, the gadolinium contrast-enhanced T1-weighted scan should use the
smallest possible axial slice thickness not exceeding 1.5 mm; the associated coronal
and sagittal sequences can be up to 2.5 mm in slice thickness; this imaging is
considered standard of care
- Note: The MRI study as part of response assessment following chemotherapy can be used
for this purpose, but the appropriate sequences must be obtained; this sequence cannot
be obtained prior to chemotherapy and is mandatory irrespective of randomization to
the experimental or control arm of this study
- Patients must sign a study-specific informed consent prior to study entry
- PRIOR TO STEP 2 REGISTRATION
- The following baseline neurocognitive assessments must be completed within 14 days
prior to Step 2 registration: HVLT-R, TMT, and COWA; the neurocognitive assessments
will be uploaded into the National Surgical Adjuvant Breast and Bowel Project,
Radiation Therapy Oncology Group, and Gynecologic Oncology Group (NRG) Oncology RAVE
system for evaluation by Dr. Wefel; once the upload is complete, a notification will
be sent to the site to proceed to Step 2; note: completed baseline neurocognitive
assessments can be uploaded at the time of Step 1 registration
- Patients must have a baseline raw score greater than 2 on the HVLT-R delayed recall
- Prior to chemotherapy or thoracic radiotherapy, patients must be defined as
limited-stage or extensive-stage SCLC after clinical staging evaluation involving the
following:
- History/physical examination;
- Computed tomography (CT) of the chest and abdomen with contrast (does not have to
be done if the patient has had a positron emission tomography (PET)/CT scan
within 8 weeks prior to initiating chemotherapy or thoracic radiotherapy)
- MRI of the brain
- For patients without evidence of extensive-stage SCLC on chest and abdomen CT and
brain MRI, a PET/CT or bone scan is required to confirm limited-stage SCLC
- Patients must be registered on study no earlier than 1 week and no later than 8 weeks
after completing chemotherapy (+/- thoracic radiotherapy)
- After chemotherapy, patients must be restaged using the same diagnostic work-up as
required pre-chemotherapy; repeat PET/CT or bone scan is not required; patients must
have:
- No central nervous system (CNS) metastases
- Radiographic partial or complete response to chemotherapy in at least one disease
site using Response Evaluation Criteria in Solid Tumors (RECIST) criteria
- No progression in any site
- Zubrod performance status 0-2
- Women of childbearing potential and male participants must practice adequate
contraception
- Women of childbearing potential must have a negative qualitative serum pregnancy test
=< 2 weeks prior to study entry
- Patients who are primary English or French speakers are eligible
Exclusion Criteria:
- Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in
overlap of radiation fields
- Radiographic evidence of CNS metastases
- Radiographic evidence of hydrocephalus
- Planned concurrent chemotherapy or anti-tumor agent during PCI
- Concomitant invasive malignancy or invasive malignancy within the past five years
other than non-melanomatous skin cancer; history of in situ carcinoma (e.g. ductal
carcinoma in situ of breast, in situ carcinoma of the cervix, vulva or larynx) is
permitted
- Contraindication to MR imaging, such as implanted metal devices or foreign bodies or
severe claustrophobia
- Severe, active comorbidity, defined as follows:
- Unstable angina and/or congestive heart failure requiring hospitalization within
the last 6 months
- Transmural myocardial infarction within the last 6 months
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy at the time of registration
- Uncontrolled, clinically significant cardiac arrhythmias
- Women of childbearing potential and male participants who are sexually active and not
willing/able to use medically acceptable forms of contraception
We found this trial at
247
sites
Geneva, Illinois 60134
Principal Investigator: Vinai Gondi
Phone: 630-315-1918
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Thomas M. Schroeder
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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666 Elm Street
Buffalo, New York 14263
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Dheerendra Prasad
Phone: 800-767-9355
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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301 University Blvd
Galveston, Texas 77555
Galveston, Texas 77555
(409) 772-1011
Principal Investigator: Todd A. Swanson
Phone: 409-772-1950
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Timothy J. Harris
Phone: 804-628-1939
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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2226 Liliha Street
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Principal Investigator: Richard Y. Lee
Phone: 808-678-9000
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1200 Old York Road
Abington, Pennsylvania 19001
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Wayne H. Pinover
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Akron, Ohio 44304
Principal Investigator: Desiree E. Doncals
Phone: 330-375-6101
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1 Akron General Avenue
Akron, Ohio 44307
Akron, Ohio 44307
Principal Investigator: Mitchel L. Fromm
Phone: 866-223-8100
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Albert Lea, Minnesota 56007
Principal Investigator: Yolanda I. Garces
Phone: 855-776-0015
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Anderson, Indiana 46016
Principal Investigator: Alexander M. Yeh
Phone: 765-646-8358
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2000 E Greenville St
Anderson, South Carolina 29621
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: Leander I. Cannick
Phone: 864-512-4651
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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5301 McAuley Drive
Ann Arbor, Michigan 48197
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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Annapolis, Maryland 21401
Principal Investigator: Luqman Dad
Phone: 443-481-1320
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Atlanta, Georgia 30303
Principal Investigator: Kristin A. Higgins
Phone: 404-489-9164
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550 Peachtree St NE
Atlanta, Georgia 30308
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Kristin A. Higgins
Phone: 888-946-7447
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, Georgia 30322
Principal Investigator: Kristin A. Higgins
Phone: 404-778-1868
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Edmund L. Simon
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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22 S Greene St
Baltimore, Maryland 21201
Baltimore, Maryland 21201
(410) 328-8667
Principal Investigator: Minesh P. Mehta
Phone: 410-328-6921
University of Maryland Medical Center Founded in 1823 as the Baltimore Infirmary, the University of...
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22 South Greene Street
Baltimore, Maryland 21201
Baltimore, Maryland 21201
410-328-7904
Principal Investigator: Pranshu Mohindra
Phone: 800-888-8823
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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401 North Broadway
Baltimore, Maryland 21287
Baltimore, Maryland 21287
410-955-5000
Principal Investigator: Kristin J. Redmond
Phone: 410-955-8804
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
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Basking Ridge, New Jersey 07920
Principal Investigator: Abraham J. Wu
Phone: 212-639-5007
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Bay City, Michigan 48706
Principal Investigator: Kiran Devisetty
Phone: 313-576-9790
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Bel Air, Maryland 21014
Principal Investigator: Jack J. Hong
Phone: 443-643-3010
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Berlin, Vermont 05602
Principal Investigator: Christopher J. Anker
Phone: 802-225-5400
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Billings, Montana 59101
Principal Investigator: Benjamin T. Marchello
Phone: 800-996-2663
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Birmingham, Alabama 35233
Principal Investigator: Michael C. Dobelbower
Phone: 205-934-0220
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Sanford Bismarck Medical Center Whether your stay in our hospital is one day for same...
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Boise, Idaho 83706
Principal Investigator: Benjamin T. Marchello
Phone: 734-712-3671
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100 E Idaho St
Boise, Idaho 83712
Boise, Idaho 83712
(208) 381-2711
Principal Investigator: Paul G. Montgomery
Phone: 800-845-4624
Saint Luke's Mountain States Tumor Institute For more than 100 years, St. Luke
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Bridgeport, Connecticut 06606
Principal Investigator: Nicholas A. Blondin
Phone: 203-576-6329
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Bronx, New York 10467
Principal Investigator: William R. Bodner
Phone: 718-379-6866
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Brookfield, Wisconsin 53045
Principal Investigator: Shannon Offerman
Phone: 262-785-2273
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263 7th Avenue
Brooklyn, New York 11215
Brooklyn, New York 11215
Principal Investigator: Hani L. Ashamalla
Phone: 718-780-3677
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Brownstown, Michigan 48183
Principal Investigator: Eleanor M. Walker
Phone: 412-339-5294
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130 S Bryn Mawr Ave
Bryn Mawr, Pennsylvania 19010
Bryn Mawr, Pennsylvania 19010
(484) 337-3000
Principal Investigator: Albert S. DeNittis
Phone: 484-476-2649
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
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Burlington, Massachusetts 01805
Principal Investigator: Klaudia U. Hunter
Phone: 781-744-8027
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Burlington, Vermont 05405
Principal Investigator: Christopher J. Anker
Phone: 802-656-4101
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: Bryan A. Faller
Phone: 573-334-2230
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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Chadds Ford, Pennsylvania 19317
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
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Charlotte, North Carolina 28204
Principal Investigator: John H. Heinzerling
Phone: 800-804-9376
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Charlotte, North Carolina 28210
Principal Investigator: John H. Heinzerling
Phone: 800-804-9376
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Charlotte, North Carolina 28262
Principal Investigator: John H. Heinzerling
Phone: 800-804-9376
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303 East Superior Street
Chicago, Illinois 60611
Chicago, Illinois 60611
Principal Investigator: Timothy J. Kruser
Phone: 312-695-1301
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1969 W Ogden Ave
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 864-6000
Principal Investigator: Thomas E. Lad
Phone: 312-864-5204
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
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1653 W. Congress Parkway
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Gaurav Marwaha
Phone: 312-942-5498
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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5680 Bow Pointe Drive
Clarkston, Michigan 48346
Clarkston, Michigan 48346
Principal Investigator: Kiran Devisetty
Phone: 313-576-9790
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Clarkston, Michigan 48346
Principal Investigator: Kiran Devisetty
Phone: 248-338-0663
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10900 Euclid Ave
Cleveland, Ohio 44106
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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2049 E 100th St
Cleveland, Ohio 44106
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: Gregory M. M. Videtic
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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18101 Lorain Avenue
Cleveland, Ohio 44111
Cleveland, Ohio 44111
216.476.7000
Principal Investigator: Gregory M. M. Videtic
Phone: 866-223-8100
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
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Columbia, Maryland 21044
Principal Investigator: Pranshu Mohindra
Phone: 443-546-1300
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Columbus, Ohio 43210
Principal Investigator: Karl E. Haglund
Phone: 800-293-5066
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Columbus, Ohio 43222
Principal Investigator: Timothy D. Moore
Phone: 614-234-5433
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Commack, New York 11725
Principal Investigator: Abraham J. Wu
Phone: 631-623-4000
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Concord, North Carolina 28025
Principal Investigator: John H. Heinzerling
Phone: 704-403-1520
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1475 Northwest 12th Avenue
Coral Gables, Florida 33146
Coral Gables, Florida 33146
Principal Investigator: Eric A. Mellon
Phone: 305-243-2647
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10 Barnes West Drive
Creve Coeur, Missouri 63141
Creve Coeur, Missouri 63141
Principal Investigator: Clifford G. Robinson
Phone: 800-600-3606
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Cumming, Georgia 30041
Principal Investigator: Edmund L. Simon
Phone: 404-303-3355
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100 North Academy Avenue
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Anand Mahadevan
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
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Dayton, Ohio 45415
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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2300 N Edward St
Decatur, Illinois 62526
Decatur, Illinois 62526
(217) 876-8121
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
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1200 Pleasant St
Des Moines, Iowa 50309
Des Moines, Iowa 50309
(515) 241-6212
Principal Investigator: Robert J. Behrens
Phone: 515-241-6727
Iowa Methodist Medical Center Iowa Methodist Medical Center was established in 1901 in a single...
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2799 W Grand Blvd
Detroit, Michigan 48202
Detroit, Michigan 48202
(313) 916-2600
Principal Investigator: Eleanor M. Walker
Phone: 313-916-1784
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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4160 John R St #2122
Detroit, Michigan 48201
Detroit, Michigan 48201
(313) 833-1785
Principal Investigator: Kiran Devisetty
Phone: 313-576-9790
Wayne State University/Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Dover, New Hampshire 03820
Principal Investigator: Arul Mahadevan
Phone: 603-740-2150
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Duluth, Minnesota 55805
Principal Investigator: Steven R. Bonin
Phone: 412-339-5294
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Dunmore, Pennsylvania 18512
Principal Investigator: Wenyin Shi
Phone: 888-808-6762
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Eau Claire, Wisconsin 54701
Principal Investigator: Yolanda I. Garces
Phone: 855-776-0015
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Eau Claire, Wisconsin 54703
Principal Investigator: Yolanda I. Garces
Phone: 855-776-0015
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Effingham, Illinois 62401
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
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Elmira, New York 14905
Principal Investigator: Chi K. Tsang
Phone: 607-271-7000
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Elyria, Ohio 44035
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
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501 E. Hampden Ave.
Englewood, Colorado 80113
Englewood, Colorado 80113
303-788-5000
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Englewood Hospital and Medical Center Englewood Hospital was incorporated in 1888 as a non-profit, non-sectarian...
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820 4th St N
Fargo, North Dakota 58102
Fargo, North Dakota 58102
(701) 234-6161
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Roger Maris Cancer Center Sanford Health is an integrated health system headquartered in the Dakotas...
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28595 Orchard Lake Road
Farmington Hills, Michigan 48334
Farmington Hills, Michigan 48334
Principal Investigator: Frank A. Vicini
Phone: 248-338-0663
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Flint, Michigan 48532
Principal Investigator: Kiran Devisetty
Phone: 313-576-9790
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302 Kensington Ave
Flint, Michigan 48503
Flint, Michigan 48503
(810) 762-8490
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
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Poudre Valley Hospital A 270-bed regional medical center offering a wide array of treatments, surgeries,...
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1600 S Andrews Ave
Fort Lauderdale, Florida 33316
Fort Lauderdale, Florida 33316
(954) 355-4400
Principal Investigator: Evan M. Landau
Phone: 954-355-5346
Broward Health Medical Center Broward Health, providing service for more than 75 years, is a...
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2200 Randallia Drive
Fort Wayne, Indiana 46805
Fort Wayne, Indiana 46805
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
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Fort Wayne, Indiana 46845
Principal Investigator: Brian K. Chang
Phone: 877-784-4673
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Franklin, Wisconsin 53132
Principal Investigator: Shannon Offerman
Phone: 262-785-2273
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40 V-Twin Drive
Gettysburg, Pennsylvania 17325
Gettysburg, Pennsylvania 17325
(717) 339-2640
Principal Investigator: Amit B. Shah
Phone: 877-441-7957
Adams Cancer Center Every day across central Pennsylvania, the people of WellSpan Health work together...
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Glen Burnie, Maryland 21061
Principal Investigator: Pranshu Mohindra
Phone: 410-553-8100
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Grafton, Wisconsin 53024
Principal Investigator: Ellen L. Ziaja
Phone: 414-302-2304
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Grand Rapids, Michigan 49503
Principal Investigator: Kathleen J. Yost
Phone: 412-339-5294
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100 Michigan St NE
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
(616) 391-1774
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Spectrum Health at Butterworth Campus Butterworth Hospital is one of four facilities that make up...
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1117 29th St S
Great Falls, Montana 59405
Great Falls, Montana 59405
(406) 771-7300
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Benefis Healthcare- Sletten Cancer Institute Benefis Hospitals has 516 beds at its two campuses (that...
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2845 Greenbrier Rd
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
(920) 288-8000
Principal Investigator: Ellen L. Ziaja
Phone: 414-302-2304
Aurora BayCare Medical Center Aurora BayCare Medical Center is a 167-bed, full-service hospital serving the...
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